{"id":"W2049930483","doi":"10.1186/1471-2164-11-481","title":"DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions","year":2010,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Innovation; Ministry of Education, Culture, Sports, Science and Technology; Institut national de la recherche scientifique","keywords":"Biology; Mitochondrial DNA; DNA methylation; Nuclear gene; Gene; Nuclear DNA; Differentially methylated regions; Epigenetics; Genetics; Human mitochondrial genetics; Molecular biology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413942,0.000153518,0.0001032046,0.0002993625,0.00008524499,0.0001392031,0.0001325794,0.0001321577,0.001201429],"category_scores_gemma":[0.0002560701,0.00008061471,0.0001175737,0.0001657654,0.0001856308,0.0001018267,0.0001290288,0.0001652746,0.0001498984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001635239,"about_ca_system_score_gemma":0.00009356969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007201535,"about_ca_topic_score_gemma":0.001152735,"domain_scores_codex":[0.9999191,0.00001188896,0.000006560364,0.00003366486,0.00001398496,0.00001492244],"domain_scores_gemma":[0.9998099,0.00003302425,0.00009087003,0.00001244937,0.00003132022,0.00002246736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000285069,0.000012065,0.03827617,0.0000653179,0.00004502804,0.0001016994,0.00006937753,0.0001312752,0.9552642,0.0001627733,0.00006347029,0.005523761],"study_design_scores_gemma":[0.00002161989,0.0002697748,0.620221,0.00002506875,0.0001580392,0.001963577,0.000123012,0.002212782,0.3723601,0.000660411,0.001972065,0.00001251497],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950455,0.0009715345,0.002955372,0.00004483746,0.000004509104,0.000008864641,0.0003471314,0.00002447372,0.0005978451],"genre_scores_gemma":[0.9986348,0.0002430375,0.0005857858,0.00001045253,0.000002773418,0.00000615047,0.0001705933,0.000004299555,0.0003421659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201429,"threshold_uncertainty_score":0.004019141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01846005337435086,"score_gpt":0.2535042141252383,"score_spread":0.2350441607508874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}