{"id":"W2049966659","doi":"10.1073/pnas.1121556109","title":"Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute on Aging; National Institutes of Health; Sherman Fairchild Foundation; Canadian Institutes of Health Research; Schott Foundation for Public Education","keywords":"Bank vole; Genetically modified mouse; Transgene; Virology; Biology; Astrogliosis; Prion protein; Infectivity; In vivo; Creutzfeldt-Jakob Syndrome; Disease; Virus; Gene; Pathology; Genetics; Central nervous system; Medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005101113,0.0006187453,0.0003316487,0.0007386302,0.0003086563,0.0005238765,0.0004334304,0.0008149457,0.001285499],"category_scores_gemma":[0.0004252315,0.0004294458,0.0003987215,0.0002399128,0.0007330627,0.0003626615,0.0004203576,0.001342348,0.00051591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003376691,"about_ca_system_score_gemma":0.0002107108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005782937,"about_ca_topic_score_gemma":0.0009454069,"domain_scores_codex":[0.9996778,0.00006797771,0.00004192149,0.00008693446,0.00007204577,0.00005322896],"domain_scores_gemma":[0.9993431,0.000133537,0.0001580466,0.0001229147,0.00004078587,0.0002015808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002592384,0.0001380027,0.0008660037,0.00003058876,0.0000240101,0.0003861811,0.0001253156,0.000185623,0.9960763,0.0007009223,0.0001023686,0.00110548],"study_design_scores_gemma":[0.0002217566,0.001724748,0.01356376,0.000056926,0.00008914195,0.003797496,0.0001769963,0.004788209,0.9704621,0.0009335917,0.004142597,0.0000425976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922395,0.0004131288,0.005211713,0.00008925432,0.00003814799,0.00006386376,0.0007262012,0.0002210568,0.0009971603],"genre_scores_gemma":[0.9877785,0.0006008352,0.00494687,0.0001056003,0.0000261096,0.0001745771,0.001534543,0.0001550661,0.004677817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285499,"threshold_uncertainty_score":0.004300416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0400123805110622,"score_gpt":0.2961968994861897,"score_spread":0.2561845189751275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}