{"id":"W2049989270","doi":"10.1016/s0960-0760(01)00025-5","title":"High metabolization of catecholestrogens by type 1 estrogen sulfotransferase (hEST1)","year":2001,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Medical Research Council Canada","keywords":"Sulfotransferase; Estrogen; Estrone; Glutathione; Cofactor; Biochemistry; Estrogen receptor; Transformation (genetics); Enzyme; Chemistry; Escherichia coli; Biology; Gene; Endocrinology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003568268,0.0002747494,0.0003373282,0.00002923492,0.00007779038,0.00001399367,0.0004460841,0.000339851,0.00001876532],"category_scores_gemma":[0.0001063894,0.0002043118,0.0001379916,0.0001588224,0.0003569956,0.000006664332,0.0001097896,0.0002133189,6.805144e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001176723,"about_ca_system_score_gemma":0.00009559348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009661981,"about_ca_topic_score_gemma":4.35715e-7,"domain_scores_codex":[0.9986588,0.0001011001,0.0005532569,0.0002581901,0.0001499866,0.0002786879],"domain_scores_gemma":[0.9987328,0.00002388,0.000398713,0.0004056824,0.0002971234,0.0001417821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006180582,0.00009175451,0.0009798715,0.00004229271,0.0002158565,0.00001187914,0.00002254754,0.00001316794,0.9969969,0.0000167616,0.0004161611,0.0005747314],"study_design_scores_gemma":[0.0008969647,0.0004345394,0.00004514654,0.00002938197,0.0001527558,0.001162124,0.0001236683,0.000001849467,0.9939369,0.0001014142,0.002914685,0.00020059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841149,0.01254366,0.002741706,0.0002779342,0.00009395958,0.00008292887,0.00006598006,0.000005290238,0.00007358186],"genre_scores_gemma":[0.9951089,0.003846826,0.0003293244,0.0001988921,0.0001898889,0.000002315342,0.0001794441,0.00002210609,0.0001223026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01099394,"threshold_uncertainty_score":0.8331593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005095491810136534,"score_gpt":0.2361840844187002,"score_spread":0.2310885926085637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}