{"id":"W2050013407","doi":"10.1038/ncomms6605","title":"Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Transcriptome; Biology; Induced pluripotent stem cell; Lineage (genetic); Cellular differentiation; Germ layer; Somatic cell; Priming (agriculture); Cell biology; Regenerative medicine; Stem cell; Reprogramming; Genetics; DNA methylation; Epigenetics; Gene; Embryonic stem cell; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002351091,0.0001594381,0.0001722633,0.0001482689,0.0001181319,0.0005741773,0.0001493219,0.0001742673,0.003211768],"category_scores_gemma":[0.0002943147,0.0001295232,0.0001949895,0.0001336835,0.0001886574,0.0002840217,0.0003735021,0.0004087636,0.0004780607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025265,"about_ca_system_score_gemma":0.0001742881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008126312,"about_ca_topic_score_gemma":0.0001616137,"domain_scores_codex":[0.9998503,0.00002982706,0.00001158076,0.00004069037,0.0000290534,0.00003849923],"domain_scores_gemma":[0.999826,0.00006433285,0.00003228329,0.00002538605,0.00002029592,0.00003172687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006176803,0.000006558993,0.0001390088,0.00001758996,0.000001896622,0.00001577977,0.0000148651,0.00007033576,0.9972981,0.0008059453,0.00004837685,0.001519803],"study_design_scores_gemma":[0.00001023288,0.00009691154,0.001942793,0.000005100787,0.00001154882,0.00006874895,0.00002632188,0.0009910499,0.9941935,0.0003909055,0.002259078,0.000003933869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980828,0.0007765412,0.009825096,0.0001852253,0.00008240248,0.00003432211,0.0006498087,0.0002553955,0.007363252],"genre_scores_gemma":[0.9965131,0.0002594538,0.00150027,0.00008218374,0.00001301799,0.00001662563,0.0003964293,0.0000735795,0.001145396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003211768,"threshold_uncertainty_score":0.01074445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193951864376019,"score_gpt":0.283757449516841,"score_spread":0.2618179308730808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}