{"id":"W2050053473","doi":"10.1152/ajpcell.00290.2012","title":"Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton","year":2012,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"RHOA; Cell biology; Transcription factor; Biology; Actin cytoskeleton; ATF4; Osmotic concentration; Cytoskeleton; Osmotic shock; Signal transduction; Unfolded protein response; Cell; Biochemistry; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138078,0.0001621764,0.0004056059,0.00002621379,0.00008237817,0.000003116347,0.0002531317,0.0001031125,0.00002187289],"category_scores_gemma":[0.00006506126,0.00009729202,0.0003027077,0.0001374058,0.0006834032,0.00001524146,0.00008713933,0.0002354468,5.042743e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001997086,"about_ca_system_score_gemma":0.00005038367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000481692,"about_ca_topic_score_gemma":0.000002762872,"domain_scores_codex":[0.9985856,0.0004182234,0.0004856705,0.0001745653,0.000105679,0.0002302882],"domain_scores_gemma":[0.9984745,0.0000652227,0.0008148242,0.0003749521,0.0002057831,0.00006476655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001788915,0.0002136194,0.001350082,0.00002635286,0.0001398145,3.086201e-8,0.0002083443,0.0001387485,0.9971769,0.00009806907,0.00004952825,0.0004196205],"study_design_scores_gemma":[0.0003595896,0.0008794552,0.1291754,0.00001774414,0.00008163961,0.00001418059,0.0005465631,0.0001164661,0.8681743,0.0002546895,0.0002880199,0.0000919297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985207,0.0006398709,0.0001234799,0.0001134406,0.000365249,0.0001300169,0.0000938357,0.000002148606,0.00001121284],"genre_scores_gemma":[0.9994801,0.0002563651,0.00003597338,0.00004067409,0.0001199326,0.000002980912,0.00004371836,0.00001272933,0.000007554393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1290026,"threshold_uncertainty_score":0.3967454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006521567410994981,"score_gpt":0.2095189471938066,"score_spread":0.2029973797828116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}