{"id":"W2050084368","doi":"10.1074/jbc.m601655200","title":"The Interaction of Piasy with Trim32, an E3-Ubiquitin Ligase Mutated in Limb-girdle Muscular Dystrophy Type 2H, Promotes Piasy Degradation and Regulates UVB-induced Keratinocyte Apoptosis through NFκB","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute","keywords":"Ubiquitin ligase; Muscular dystrophy; Ubiquitin; Apoptosis; Cell biology; Chemistry; Medicine; Biology; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003767854,0.0002008611,0.0002801282,0.00002471028,0.00009396538,0.00004904739,0.0001818751,0.0002586154,0.00001229999],"category_scores_gemma":[0.0002068336,0.000120365,0.00009067512,0.0001454858,0.0001490868,0.00002350041,0.0000515666,0.0002628309,4.664967e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002704637,"about_ca_system_score_gemma":0.00007530498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003175159,"about_ca_topic_score_gemma":0.000009626388,"domain_scores_codex":[0.9987077,0.0001323081,0.0005416836,0.0002522776,0.0001502029,0.0002158433],"domain_scores_gemma":[0.9989207,0.00005743674,0.0005051945,0.0001943259,0.0002533248,0.00006906721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001304307,0.0001907301,0.0008824326,0.00003765732,0.00004217867,0.000008499645,0.00004061708,0.00004430762,0.9962987,0.000008548071,0.00002168578,0.001120364],"study_design_scores_gemma":[0.0009263754,0.002340771,0.001507696,0.00008260601,0.00002566252,0.0001643032,0.0003227747,0.00007949884,0.9939194,0.0001831035,0.0002878581,0.0001599088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986299,0.0007303732,0.00008116524,0.0001201495,0.00003871047,0.0001599974,0.000009958746,0.000007789731,0.0002219824],"genre_scores_gemma":[0.9981019,0.0002696621,0.001209694,0.00002527331,0.0002299926,0.000008450758,0.00009487898,0.00001389185,0.00004626199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00237923,"threshold_uncertainty_score":0.4908344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0219197637829522,"score_gpt":0.2568503339064457,"score_spread":0.2349305701234935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}