{"id":"W2050091769","doi":"10.1074/jbc.m110.106591","title":"Na+/H+ Exchanger Regulatory Factor-1 Is Involved in Chemokine Receptor Homodimer CCR5 Internalization and Signal Transduction but Does Not Affect CXCR4 Homodimer or CXCR4-CCR5 Heterodimer","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Chemokine receptor; Cell biology; G protein-coupled receptor; Signal transduction; CCR1; Receptor; Scaffold protein; Signal transducing adaptor protein; PDZ domain; Biology; Chemistry; Chemokine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413139,0.0002062275,0.0002780535,0.0001198367,0.0002951445,0.0002812015,0.0001953325,0.0004056403,0.003303493],"category_scores_gemma":[0.0001037468,0.000113046,0.0004617806,0.00007415631,0.0002187583,0.00030444,0.0001733637,0.0005636719,0.0006724758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003454196,"about_ca_system_score_gemma":0.0002082005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008085531,"about_ca_topic_score_gemma":0.0007417783,"domain_scores_codex":[0.9997454,0.00003169713,0.00001939119,0.00006169728,0.00006089689,0.00008086854],"domain_scores_gemma":[0.9999247,0.000008746822,0.00002005946,0.000009526749,0.000008691484,0.00002829954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002946031,0.00003169699,0.0002867918,0.00005352498,0.000008022459,0.000098517,0.00001256681,0.00002847389,0.9976543,0.0001878098,0.000112508,0.001231372],"study_design_scores_gemma":[0.00008013159,0.000326174,0.03105237,0.00001472233,0.00004058742,0.0008801049,0.00007666998,0.00140887,0.9553791,0.0001384666,0.01059212,0.00001068458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888645,0.003584575,0.002763591,0.0004098031,0.0001153155,0.00003793531,0.0005681425,0.0001090782,0.003547026],"genre_scores_gemma":[0.9925565,0.0007334873,0.00102174,0.0001145301,0.00001997513,0.00002537385,0.0006787754,0.00001498885,0.004834645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003303493,"threshold_uncertainty_score":0.0110513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224104277661676,"score_gpt":0.2451759056394089,"score_spread":0.2227654778732413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}