{"id":"W2050091769","doi":"10.1074/jbc.m110.106591","title":"Na+/H+ Exchanger Regulatory Factor-1 Is Involved in Chemokine Receptor Homodimer CCR5 Internalization and Signal Transduction but Does Not Affect CXCR4 Homodimer or CXCR4-CCR5 Heterodimer","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Chemokine receptor; Cell biology; G protein-coupled receptor; Signal transduction; CCR1; Receptor; Scaffold protein; Signal transducing adaptor protein; PDZ domain; Biology; Chemistry; Chemokine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004357868,0.0003110694,0.0005047891,0.0001267396,0.00009981886,0.00003744417,0.0002042702,0.0008942306,0.01790705],"category_scores_gemma":[0.0001602212,0.0001934389,0.0002245716,0.0001263312,0.0003302028,0.0002974013,0.00005105706,0.00133655,0.00004378921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008376678,"about_ca_system_score_gemma":0.00005585826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003159563,"about_ca_topic_score_gemma":0.000007264633,"domain_scores_codex":[0.9983528,0.0001485102,0.0007204614,0.0003613155,0.00009501964,0.0003218543],"domain_scores_gemma":[0.9988975,0.0001483883,0.0004913326,0.0001986159,0.000193882,0.0000702981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00180499,0.000245402,0.003270649,0.00004823269,0.0001427189,0.000008183971,0.0002510842,9.55965e-7,0.9877254,0.000002508208,0.002231237,0.004268667],"study_design_scores_gemma":[0.001671733,0.0003304625,0.004365787,0.00009277657,0.00003971929,0.0003691383,0.0002294096,0.000009714254,0.9699522,0.00002377541,0.02264869,0.0002665689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944612,0.001162841,0.0002685025,0.0006936949,0.003129861,0.0001341295,0.00002188398,0.00003270464,0.00009514314],"genre_scores_gemma":[0.9920171,0.0005565702,0.0000857854,0.0003708935,0.0003695918,0.000009941207,0.00006276846,0.00002063346,0.006506748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02041745,"threshold_uncertainty_score":0.9829907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224104277661676,"score_gpt":0.2451759056394089,"score_spread":0.2227654778732413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}