{"id":"W2050094093","doi":"10.1016/j.virol.2010.01.032","title":"Human antibodies to herpes simplex virus type 1 glycoprotein C are neutralizing and target the heparan sulfate-binding domain","year":2010,"lang":"en","type":"article","venue":"Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medicinska Forskningsrådet; University of British Columbia; University of Pennsylvania","keywords":"Biology; Herpes simplex virus; Monoclonal antibody; HaCaT; Antibody; Infectivity; Virology; Heparan sulfate; Glycoprotein; Molecular biology; Epitope; Herpesvirus glycoprotein B; Cell culture; Virus; Viral entry; Cell; Biochemistry; Immunology; Viral replication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002565555,0.0003957187,0.0002358188,0.0002985804,0.0001984434,0.0002971695,0.0002479278,0.0003880666,0.002416035],"category_scores_gemma":[0.0003798581,0.0001062085,0.0002497106,0.0002064825,0.0002280853,0.0001353862,0.000200059,0.0004263771,0.0005383088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004850562,"about_ca_system_score_gemma":0.0003691442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002228621,"about_ca_topic_score_gemma":0.00185747,"domain_scores_codex":[0.9998288,0.00003108237,0.000005111154,0.00001942553,0.0000585426,0.00005695803],"domain_scores_gemma":[0.9998318,0.0000617933,0.00002324788,0.00001708732,0.00003595404,0.00003010663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003969589,0.0002581081,0.004222282,0.0001726691,0.00008751296,0.0002806655,0.000112057,0.0004032332,0.9226409,0.001699365,0.002443417,0.06728278],"study_design_scores_gemma":[0.0001880775,0.002102452,0.04492643,0.00005294011,0.0001064803,0.002554026,0.0001076702,0.002748697,0.898423,0.0009612127,0.04780574,0.00002325761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612238,0.009437065,0.005993025,0.0003298264,0.0001811001,0.000191045,0.0002302963,0.0001590841,0.02225482],"genre_scores_gemma":[0.9883671,0.003096343,0.001684304,0.0003282482,0.00007250133,0.00003318213,0.0003628911,0.00001425065,0.006041239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002416035,"threshold_uncertainty_score":0.008082449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02047892546706615,"score_gpt":0.3153552712396383,"score_spread":0.2948763457725722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}