{"id":"W2050122964","doi":"10.1016/s0197-4580(00)00220-7","title":"Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment","year":2000,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institutes of Health; Heart and Stroke Foundation of Canada; Rockefeller Foundation","keywords":"Excitotoxicity; Cyclin-dependent kinase; Neurodegeneration; Neuroprotection; Programmed cell death; Kainic acid; Cell biology; Downregulation and upregulation; Biology; Kinase; Neuroscience; Cell cycle; Apoptosis; Glutamate receptor; Biochemistry; Medicine; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003744832,0.0001331762,0.0002155195,0.00009501485,0.00005210736,0.000004393898,0.00004506717,0.00008163204,0.00002022851],"category_scores_gemma":[0.00001112398,0.0001300544,0.00005249888,0.00009774839,0.00003774617,0.0000354697,0.00001105959,0.00008626984,0.000001566778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004600909,"about_ca_system_score_gemma":0.00004959807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002396995,"about_ca_topic_score_gemma":0.00001660791,"domain_scores_codex":[0.9991368,0.00005434245,0.0002332859,0.0003435467,0.00003484366,0.0001971678],"domain_scores_gemma":[0.9996034,0.00006078779,0.00006479121,0.0001833661,0.00002716291,0.00006050521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001101524,0.0002508145,0.01597255,0.00004664117,0.00001818729,0.000002669892,0.0001156052,0.001365287,0.9793814,0.00009770328,0.0002806574,0.002358295],"study_design_scores_gemma":[0.004072993,0.00144026,0.2271709,0.00004889737,0.0001040451,0.00005063693,0.000007867003,0.002547028,0.763136,0.00009696095,0.001145363,0.000179079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973362,0.0006380826,0.00002824341,0.0009763271,0.00005864207,0.000607993,0.0001354629,0.00003087668,0.0001881683],"genre_scores_gemma":[0.9988889,0.0003058609,0.0001054513,0.0002001367,0.00003684369,0.00007511079,0.0001727935,0.00002384874,0.000191057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2162455,"threshold_uncertainty_score":0.5303465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369493536830766,"score_gpt":0.2575658312284411,"score_spread":0.2438708958601335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}