{"id":"W2050179344","doi":"10.1074/jbc.m311014200","title":"Phosphorylation-induced Conformational Changes of Cystic Fibrosis Transmembrane Conductance Regulator Monitored by Attenuated Total Reflection-Fourier Transform IR Spectroscopy and Fluorescence Spectroscopy","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Phosphorylation; Cystic fibrosis transmembrane conductance regulator; Chemistry; Protein phosphorylation; Transmembrane protein; Cyclic nucleotide-binding domain; Transmembrane domain; Biophysics; Quenching (fluorescence); Biochemistry; Protein kinase A; Nucleotide; Biology; Fluorescence; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002302552,0.0002417011,0.0001537854,0.0001579828,0.0001560462,0.000126568,0.0001965333,0.0003232106,0.001225915],"category_scores_gemma":[0.0002811637,0.0001545893,0.0002103022,0.0001292722,0.0002398693,0.0002397461,0.0001071406,0.0005863285,0.0002355155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351471,"about_ca_system_score_gemma":0.00007550878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002537378,"about_ca_topic_score_gemma":0.0002067398,"domain_scores_codex":[0.9998893,0.00002872001,0.000004442372,0.00002034519,0.00003095586,0.00002632567],"domain_scores_gemma":[0.9998976,0.000028811,0.00003253227,0.00001039518,0.00001593164,0.00001463396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007605954,0.00001181213,0.00007733352,0.00001616169,0.000002771058,0.00003088805,0.00001794155,0.00005631039,0.9991778,0.00005105324,0.00001897659,0.0004628997],"study_design_scores_gemma":[0.000019924,0.0002556655,0.004878476,0.000004834506,0.00001122824,0.0002801322,0.00003703541,0.001854911,0.9920621,0.00007266959,0.000512786,0.00001036423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944218,0.0007312203,0.003492793,0.00009158988,0.00002200086,0.00001558692,0.0001266698,0.00004534006,0.001052879],"genre_scores_gemma":[0.9931409,0.0006647689,0.004661287,0.00006225534,0.00001025235,0.00002930471,0.0002391658,0.00001635941,0.001175612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225915,"threshold_uncertainty_score":0.004101098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01778844612335584,"score_gpt":0.2930370621406072,"score_spread":0.2752486160172514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}