{"id":"W2050186600","doi":"10.1182/blood.v97.10.3075","title":"Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner","year":2001,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":502,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Alberta","funders":"Canadian Blood Services; National Heart, Lung, and Blood Institute; University of Pennsylvania","keywords":"Autocrine signalling; Biology; Hematopoietic growth factor; Haematopoiesis; Paracrine signalling; Hepatocyte growth factor; Interleukin 3; Growth factor; Chemokine; Stem cell factor; Cell biology; Thrombopoietin; Cancer research; Molecular biology; Immunology; Cell culture; T cell; Stem cell; Inflammation; Antigen-presenting cell; Receptor; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008719185,0.0005280725,0.0008082881,0.0002216358,0.0001883326,0.0000912774,0.00009332559,0.0001899523,0.00004701392],"category_scores_gemma":[0.00001873257,0.0004520324,0.00005183087,0.0002839541,0.0001763631,0.0003694108,0.0001392891,0.0002293507,0.00000260395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002536616,"about_ca_system_score_gemma":0.00002034608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000524869,"about_ca_topic_score_gemma":0.0006667124,"domain_scores_codex":[0.997934,0.00004688828,0.0004372867,0.0007210984,0.0002792877,0.0005814598],"domain_scores_gemma":[0.999055,0.0000399524,0.0001580986,0.0003120229,0.00006142736,0.0003735569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003455052,0.001871939,0.9633347,0.0004359849,0.0003628143,0.001976767,0.0005830753,0.00000142085,0.02980993,0.00006277449,0.0006769449,0.0005381366],"study_design_scores_gemma":[0.01467159,0.0009532407,0.9469505,0.0003265351,0.000444439,0.002195438,0.0004364102,0.0001390446,0.03232751,0.0002393808,0.0006250296,0.0006908567],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968011,0.00192742,0.000003955018,0.0003453853,0.00003624017,0.0005069993,0.00009393774,0.0001250714,0.0001598991],"genre_scores_gemma":[0.9977948,0.0009564129,0.0001558425,0.000127366,0.00005865642,0.00002930729,0.000319574,0.00007194876,0.0004860876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01638418,"threshold_uncertainty_score":0.9997932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008216117868122598,"score_gpt":0.2274349287152443,"score_spread":0.2192188108471217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}