{"id":"W2050186600","doi":"10.1182/blood.v97.10.3075","title":"Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner","year":2001,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":502,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Alberta","funders":"Canadian Blood Services; National Heart, Lung, and Blood Institute; University of Pennsylvania","keywords":"Autocrine signalling; Biology; Hematopoietic growth factor; Haematopoiesis; Paracrine signalling; Hepatocyte growth factor; Interleukin 3; Growth factor; Chemokine; Stem cell factor; Cell biology; Thrombopoietin; Cancer research; Molecular biology; Immunology; Cell culture; T cell; Stem cell; Inflammation; Antigen-presenting cell; Receptor; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011955,0.0004394923,0.0001729683,0.0003606356,0.0001498986,0.0003068545,0.00008771863,0.0001714682,0.001327748],"category_scores_gemma":[0.000168551,0.000122244,0.0001280302,0.0002015573,0.0001807196,0.0001622827,0.0001995416,0.0002437547,0.0003963873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001328829,"about_ca_system_score_gemma":0.0001914026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003718474,"about_ca_topic_score_gemma":0.0005741094,"domain_scores_codex":[0.9999017,0.00001887419,0.000007065796,0.00002038518,0.00003089699,0.0000212015],"domain_scores_gemma":[0.9999099,0.00002188656,0.00002206954,0.00001005611,0.0000184144,0.00001775707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008760244,0.00001134525,0.001467807,0.00004917117,0.00000362095,0.0001237198,0.00003659905,0.00005911586,0.9867659,0.0001303465,0.00006675192,0.01119793],"study_design_scores_gemma":[0.00003847428,0.0005574999,0.03526772,0.00003753101,0.00004549159,0.00231573,0.0001638123,0.0009153104,0.943834,0.0004420339,0.01636868,0.00001374607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750294,0.01151465,0.009803102,0.0001423572,0.00002693448,0.00008906558,0.0007029523,0.0001968913,0.00249461],"genre_scores_gemma":[0.9764488,0.005973139,0.0119648,0.00007254446,0.0000469064,0.00008578705,0.001383691,0.00002706379,0.003997215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327748,"threshold_uncertainty_score":0.004441798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008216117868122598,"score_gpt":0.2274349287152443,"score_spread":0.2192188108471217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}