{"id":"W2050234611","doi":"10.1002/jcb.20024","title":"Reduced type I collagen utilization: A pathogenic mechanism in COL5A1 haplo‐insufficient Ehlers–Danlos syndrome","year":2004,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Canadian Arthritis Network; Thomas Jefferson University","keywords":"Hydroxyproline; Type I collagen; Collagen, type I, alpha 1; Collagen fibril; Ehlers–Danlos syndrome; Osteogenesis imperfecta; Fibroblast; Chemistry; Collagen receptor; Matrix (chemical analysis); Connective tissue; Fibril; Matrix metalloproteinase; Proline; Procollagen peptidase; Extracellular matrix; Endocrinology; Biophysics; Cell; Biochemistry; Anatomy; Pathology; Biology; In vitro; Medicine; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004769663,0.0002168942,0.0002884544,0.0001366138,0.00006751588,0.00003278663,0.0004260328,0.0002752398,0.00009023439],"category_scores_gemma":[0.000385117,0.000225011,0.0001729569,0.0004664603,0.00008712222,0.000007394582,0.0001382536,0.0002047078,0.00001375253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725991,"about_ca_system_score_gemma":0.0007912244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005600948,"about_ca_topic_score_gemma":0.000006782659,"domain_scores_codex":[0.9982756,0.00007285688,0.0005084915,0.0003443194,0.0004451992,0.0003535616],"domain_scores_gemma":[0.9986807,0.0000123312,0.0002665079,0.0003784805,0.0004786368,0.000183358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001783931,0.0003360939,0.0001467566,0.00005918994,0.00007408651,0.0003989958,0.00008315749,0.0002361984,0.9981673,0.00004218337,0.0001350557,0.0001425299],"study_design_scores_gemma":[0.001685161,0.00058577,0.0002639172,0.00009497617,0.00002545036,0.0005895723,0.0004080808,0.00002260306,0.9951925,0.0003002729,0.000592829,0.000238851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993048,0.004429141,0.001570403,0.0002215131,0.0001829547,0.0002190147,0.00001143256,0.000006298984,0.0003112262],"genre_scores_gemma":[0.9985623,0.0002831233,0.0003918351,0.00005230326,0.0001283312,0.000007064277,0.00005364796,0.00003697223,0.0004843623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005514345,"threshold_uncertainty_score":0.9175683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02440537984501043,"score_gpt":0.2842139635472575,"score_spread":0.259808583702247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}