{"id":"W2050238491","doi":"10.1002/cmdc.200900076","title":"PAMAM Dendrimers Mediate siRNA Delivery to Target Hsp27 and Produce Potent Antiproliferative Effects on Prostate Cancer Cells","year":2009,"lang":"en","type":"article","venue":"ChemMedChem","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Gene silencing; RNA interference; Small interfering RNA; Hsp27; Prostate cancer; Dendrimer; Cancer research; Chemistry; Cancer cell; Cancer; Transfection; Cell biology; Biology; Heat shock protein; Biochemistry; RNA; Gene; Hsp70","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000993046,0.0002864573,0.0001555128,0.0001478523,0.0001122902,0.0001324524,0.0001409817,0.0002041788,0.0009461106],"category_scores_gemma":[0.00009606484,0.0001062927,0.0001609419,0.00009705098,0.0001411698,0.0001430522,0.0001442348,0.0002983041,0.0003853453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635414,"about_ca_system_score_gemma":0.0001711159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002688061,"about_ca_topic_score_gemma":0.0004783351,"domain_scores_codex":[0.999943,0.000008246318,0.000003622891,0.0000126339,0.00001707198,0.00001546509],"domain_scores_gemma":[0.999958,0.00001011642,0.00001239079,0.000005173925,0.000006653,0.000007629172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002775981,0.000007360502,0.00003200432,0.00002440509,0.000003054982,0.00003034368,0.000007325208,0.00008000436,0.9980215,0.0001624935,0.00004888437,0.001554981],"study_design_scores_gemma":[0.000005172205,0.00007133815,0.0002296957,8.866871e-7,0.000003617985,0.00008731168,0.000002605624,0.0002964262,0.9974505,0.00002131431,0.001829842,0.000001366408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699121,0.003280452,0.0200063,0.0002217609,0.00005816916,0.00009890275,0.0002358178,0.0003027957,0.005883658],"genre_scores_gemma":[0.9871231,0.001131425,0.005798942,0.0000630366,0.00001202508,0.00005100957,0.0002164567,0.00002634592,0.005577638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009461106,"threshold_uncertainty_score":0.003165007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005746636132261595,"score_gpt":0.2377800274545327,"score_spread":0.2320333913222711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}