{"id":"W2050240511","doi":"10.1006/bcmd.2000.0296","title":"Detailed Mapping of Methylcytosine Positions at the CpG Island Surrounding the Pa Promoter at the bcr-abl Locus in CML Patients and in Two Cell Lines, K562 and BV173","year":2000,"lang":"en","type":"article","venue":"Blood Cells Molecules and Diseases","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Université Laval","keywords":"Biology; DNA methylation; Methylation; ABL; breakpoint cluster region; Molecular biology; Chronic myelogenous leukemia; Restriction enzyme; Philadelphia chromosome; K562 cells; Promoter; CpG site; Genetics; Cancer research; Gene; Chromosomal translocation; Leukemia; Tyrosine kinase; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006544329,0.00007624463,0.0001344304,0.0003427902,0.0001626685,0.0001212104,0.0001094065,0.0001644028,0.0018132],"category_scores_gemma":[0.0001771987,0.0001225043,0.0001377644,0.0001889413,0.0001284275,0.00007141384,0.0001074261,0.0002414574,0.0002941708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001214815,"about_ca_system_score_gemma":0.000106217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002537196,"about_ca_topic_score_gemma":0.003168965,"domain_scores_codex":[0.9999537,0.000007668251,0.000003056614,0.00001229187,0.000009050242,0.00001407741],"domain_scores_gemma":[0.999902,0.0000317275,0.00002062812,0.00001086097,0.00001606336,0.00001867269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003259715,0.00001111121,0.004154895,0.00001851885,0.000008145788,0.0000465563,0.0000655113,0.0000827508,0.9935621,0.00008226445,0.00002271088,0.001619475],"study_design_scores_gemma":[0.00005501197,0.0006120462,0.3254003,0.00001113095,0.00008093233,0.001318916,0.0002491212,0.001799242,0.6678565,0.0002139253,0.00239107,0.00001176879],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973515,0.0003808785,0.0009476789,0.00002800327,0.000004328253,0.000008766389,0.0006020784,0.00001310883,0.0006637108],"genre_scores_gemma":[0.9981767,0.0001041345,0.0004698119,0.0000112836,0.000001656847,0.00001095377,0.0005499283,0.000004693461,0.0006708759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002537196,"threshold_uncertainty_score":0.006065786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006462438300409976,"score_gpt":0.2274337295635653,"score_spread":0.2209712912631553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}