{"id":"W2050240511","doi":"10.1006/bcmd.2000.0296","title":"Detailed Mapping of Methylcytosine Positions at the CpG Island Surrounding the Pa Promoter at the bcr-abl Locus in CML Patients and in Two Cell Lines, K562 and BV173","year":2000,"lang":"en","type":"article","venue":"Blood Cells Molecules and Diseases","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Université Laval","keywords":"Biology; DNA methylation; Methylation; ABL; breakpoint cluster region; Molecular biology; Chronic myelogenous leukemia; Restriction enzyme; Philadelphia chromosome; K562 cells; Promoter; CpG site; Genetics; Cancer research; Gene; Chromosomal translocation; Leukemia; Tyrosine kinase; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208685,0.0002146592,0.0002789998,0.00006229689,0.0001959922,0.00003884555,0.00007528251,0.00004146278,0.0001276436],"category_scores_gemma":[0.00002463451,0.0001094645,0.00005699287,0.0001824852,0.0002230859,0.00005028098,0.000134923,0.0001120431,0.00000329563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008572706,"about_ca_system_score_gemma":0.00006102221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005329946,"about_ca_topic_score_gemma":0.001480495,"domain_scores_codex":[0.9987651,0.0001552079,0.000300187,0.0003115376,0.0002015658,0.0002664031],"domain_scores_gemma":[0.9992341,0.0002598155,0.00009020602,0.0002834079,0.00002900934,0.0001033922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009713654,0.001989064,0.9465061,0.0005465831,0.0002529488,0.0001857725,0.002189643,0.0001124441,0.03807086,0.00001451791,0.0004598626,0.008700842],"study_design_scores_gemma":[0.02831922,0.0005483166,0.9156082,0.0008189603,0.001857666,0.0001035263,0.0006450015,0.0009821947,0.04912234,0.0002415867,0.001252117,0.0005008843],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825287,0.01559952,0.000002807595,0.0004856069,0.00001942028,0.0008409093,0.0001313892,0.000008348977,0.0003832526],"genre_scores_gemma":[0.9970222,0.001800294,0.00003613491,0.0002650404,0.00003048874,0.00006619293,0.00007203462,0.00002066017,0.0006870088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03089791,"threshold_uncertainty_score":0.4463834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006462438300409976,"score_gpt":0.2274337295635653,"score_spread":0.2209712912631553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}