{"id":"W2050252182","doi":"10.1038/ng.631","title":"Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis","year":2010,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":217,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Saint-Luc; University of Calgary; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université de Montréal; University of Alberta; Toronto Western Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Canada Research Chairs; University Health Network; American Gastroenterological Association","keywords":"Primary biliary cirrhosis; Biology; Genome-wide association study; IRF5; Genetic association; Genetics; Cirrhosis; Single-nucleotide polymorphism; Gene; Internal medicine; Immunology; Genotype; Medicine; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325828,0.0002013911,0.000290857,0.00006512331,0.0001492011,0.0000258051,0.0001211582,0.0005283501,0.0001513061],"category_scores_gemma":[0.0001744588,0.0001531999,0.00006097136,0.0002049217,0.0001222063,0.00004431405,0.0001496992,0.001041534,0.0000116806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007035077,"about_ca_system_score_gemma":0.0001355303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001380093,"about_ca_topic_score_gemma":0.00006304582,"domain_scores_codex":[0.9988871,0.0000417006,0.0001540706,0.0003007127,0.0003382106,0.0002782288],"domain_scores_gemma":[0.998835,0.00007979816,0.0001146014,0.0004992336,0.0002208357,0.000250494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002617228,0.0003341674,0.9781677,0.0001104636,0.0002413256,0.00008130143,0.0001447446,7.790063e-7,0.01184793,0.000010154,0.006624078,0.002175611],"study_design_scores_gemma":[0.001677304,0.0002363915,0.9910271,0.0001059024,0.0004205179,0.00005441672,0.00004423673,0.00006802243,0.00145062,0.00005230902,0.004663839,0.0001993592],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927352,0.003940593,0.000003165388,0.0006745042,0.0003594281,0.0003065842,0.0000988596,0.0000587222,0.001822911],"genre_scores_gemma":[0.9950227,0.000501505,0.0007644618,0.002257944,0.0002055203,0.000006442155,0.0001772591,0.00003915528,0.001025032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01285936,"threshold_uncertainty_score":0.6247311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006444183592760626,"score_gpt":0.2251689921311321,"score_spread":0.2187248085383715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}