{"id":"W2050252182","doi":"10.1038/ng.631","title":"Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis","year":2010,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":217,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Saint-Luc; University of Calgary; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université de Montréal; University of Alberta; Toronto Western Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Canada Research Chairs; University Health Network; American Gastroenterological Association","keywords":"Primary biliary cirrhosis; Biology; Genome-wide association study; IRF5; Genetic association; Genetics; Cirrhosis; Single-nucleotide polymorphism; Gene; Internal medicine; Immunology; Genotype; Medicine; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004244677,0.001003867,0.0005485621,0.001669733,0.0006713783,0.0004952489,0.0007066487,0.001488212,0.007136759],"category_scores_gemma":[0.002066043,0.0003927418,0.0006664104,0.001448431,0.0005553365,0.0002984736,0.0003899809,0.0007710904,0.0006803796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407181,"about_ca_system_score_gemma":0.0002192553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00184844,"about_ca_topic_score_gemma":0.00210306,"domain_scores_codex":[0.9994854,0.0001583188,0.00005996245,0.0001099228,0.00008321484,0.0001033088],"domain_scores_gemma":[0.9984272,0.0005725703,0.0006307082,0.00007950306,0.00005991233,0.0002301777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01006722,0.000437256,0.808301,0.0002130497,0.001011883,0.04142936,0.0007426378,0.001122746,0.1141366,0.001290469,0.002300873,0.01894685],"study_design_scores_gemma":[0.0002958677,0.000454505,0.9330177,0.00006547142,0.0006492701,0.05094098,0.0003769992,0.001766981,0.008745422,0.001308039,0.002323329,0.00005538489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978676,0.0003593734,0.0003346518,0.0002403206,0.00003542526,0.000008404581,0.000284566,0.00002497153,0.0008447036],"genre_scores_gemma":[0.9988348,0.00007117256,0.0003018317,0.00005243698,0.00003925274,0.000006167668,0.0001389175,0.00001260758,0.0005427665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007136759,"threshold_uncertainty_score":0.02387482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006444183592760626,"score_gpt":0.2251689921311321,"score_spread":0.2187248085383715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}