{"id":"W2050261944","doi":"10.1016/j.chembiol.2012.04.001","title":"Selective Inhibition of USP7","year":2012,"lang":"en","type":"letter","venue":"Chemistry & Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Biotechnology Research Institute","funders":"","keywords":"Deubiquitinating enzyme; Gene knockdown; Small molecule; Biology; Chemical biology; Cancer research; Computational biology; Biochemistry; Ubiquitin; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001445728,0.0003528789,0.0003970851,0.00003042148,0.00004423693,0.000006038592,0.0002452678,0.002345185,0.0003078647],"category_scores_gemma":[0.00009855174,0.0003471135,0.0002208811,0.00007671253,0.0002798857,0.000001886782,0.0001734364,0.0007811193,0.00003248102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002853957,"about_ca_system_score_gemma":0.0001427817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001151758,"about_ca_topic_score_gemma":7.08341e-7,"domain_scores_codex":[0.9984593,0.00009010942,0.0003393207,0.0005323253,0.00009007747,0.0004888341],"domain_scores_gemma":[0.9989086,0.00002437839,0.0003306941,0.000510306,0.0001629666,0.00006299463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002143079,0.00002189836,0.0002094791,0.0002227371,0.00007312293,0.000003433376,0.00001154235,9.964771e-8,0.7053065,0.000003187706,0.2938331,0.0002935358],"study_design_scores_gemma":[0.0001447305,0.00006586086,0.00001411307,0.00002164176,0.00002333475,0.00002591279,0.000003583265,2.33352e-7,0.5512589,0.00009897436,0.4481418,0.0002008728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7953218,0.01485508,0.0006358294,0.0777551,0.001662817,0.001484485,0.003045104,0.0001648409,0.105075],"genre_scores_gemma":[0.8195121,0.0004489739,0.0004698323,0.128038,0.01915611,0.0002303702,0.02389668,0.0001645084,0.008083384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1543087,"threshold_uncertainty_score":0.9998981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364744835707417,"score_gpt":0.2424918485682516,"score_spread":0.2288444002111774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}