{"id":"W2050262449","doi":"10.1042/bj20090228","title":"The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity","year":2009,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Weizmann Institute of Science","keywords":"Kinase; MAPK/ERK pathway; Phosphorylation; Alternative splicing; Cell biology; RNA splicing; C-terminus; Biology; Gene isoform; Phosphorylation cascade; Protein kinase A; Enzyme activator; Signal transduction; Biochemistry; Gene; Protein phosphorylation; Amino acid; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339226,0.0003542729,0.0002752274,0.0001326651,0.0002669317,0.0003593413,0.0002934319,0.0003506971,0.001936896],"category_scores_gemma":[0.0002101863,0.000125406,0.0003496374,0.000156166,0.0003801269,0.0002889065,0.0002764247,0.0006887314,0.001600105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003896724,"about_ca_system_score_gemma":0.0002601068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005191235,"about_ca_topic_score_gemma":0.0005606376,"domain_scores_codex":[0.9998871,0.00001368851,0.00001080222,0.00004318164,0.00002603194,0.00001920737],"domain_scores_gemma":[0.999712,0.00005658265,0.0000843918,0.00003955995,0.00003270682,0.00007472024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001942167,0.00001732442,0.0003471424,0.00005551279,0.000003862836,0.00006649709,0.00001618582,0.0001011093,0.9971361,0.0001438757,0.00003984857,0.001878284],"study_design_scores_gemma":[0.00004067858,0.0002348404,0.0181902,0.00002266048,0.0000176315,0.001490691,0.00003835309,0.001126278,0.9688867,0.0001682883,0.009763916,0.00001969592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985594,0.003276233,0.008337997,0.000190187,0.00004340347,0.00003674363,0.0006833816,0.0001062464,0.001731953],"genre_scores_gemma":[0.9856207,0.0007350867,0.009172243,0.0001138062,0.00003650102,0.000053811,0.00146282,0.00003631322,0.002768701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001936896,"threshold_uncertainty_score":0.006479502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008773595567492644,"score_gpt":0.2521311065880109,"score_spread":0.2433575110205183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}