{"id":"W2050269784","doi":"10.1016/j.bpj.2009.12.2866","title":"Reductions in Ventricular Ca2+ Current Occur Independently of Cardiac Remodelling in Transgenic Mice with Cardiac Specific Overexpression of the Human Type 1 Angiotensin II Receptor","year":2010,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Montreal Heart Institute","funders":"","keywords":"Contractility; Internal medicine; Endocrinology; Angiotensin II; Muscle hypertrophy; Genetically modified mouse; Receptor; Ventricular hypertrophy; Transgene; Cardiac hypertrophy; Biology; Myocyte; Renin–angiotensin system; Contraction (grammar); Chemistry; Medicine; Left ventricular hypertrophy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002967689,0.0009829304,0.0006596263,0.0008928895,0.000227664,0.0006961523,0.0005273924,0.0009202952,0.002684972],"category_scores_gemma":[0.0004467048,0.0005035205,0.000550658,0.0002692632,0.0012172,0.000665834,0.0003549378,0.002123934,0.0007741695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003352619,"about_ca_system_score_gemma":0.0002475794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004050344,"about_ca_topic_score_gemma":0.0007540308,"domain_scores_codex":[0.9996043,0.00003923562,0.00004110654,0.0001149971,0.0001094649,0.00009084536],"domain_scores_gemma":[0.9990456,0.0001683226,0.0003767495,0.00007994092,0.00004633885,0.0002830832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002174471,0.00003525618,0.00009722946,0.00001147765,0.000008204271,0.0001199229,0.00001389412,0.00002016053,0.9989429,0.00007874002,0.00004674937,0.0004079654],"study_design_scores_gemma":[0.0004609954,0.0007647309,0.02073249,0.00002398985,0.0001799948,0.00249103,0.000113523,0.001767464,0.9708547,0.0006707232,0.001900829,0.00003949005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989976,0.0008029001,0.006042339,0.0004234514,0.0002056223,0.00003005277,0.0007303603,0.0006034879,0.001185806],"genre_scores_gemma":[0.9918282,0.0006114133,0.002184356,0.0002048181,0.00008651405,0.00008275345,0.0007067833,0.0002873038,0.004007942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002684972,"threshold_uncertainty_score":0.008982182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134875891568764,"score_gpt":0.2578759421160348,"score_spread":0.2443883529591584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}