{"id":"W2050299929","doi":"10.4161/cc.10.12.15882","title":"UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation","year":2011,"lang":"en","type":"review","venue":"Cell Cycle","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heritage Medical Research Clinic; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Alberta Cancer Foundation","keywords":"Mdm2; Ubiquitin ligase; Transactivation; Ubiquitin; Biology; Cell biology; Suppressor; DNA ligase; Cancer research; Apoptosis; Biochemistry; Transcription factor; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002404878,0.0008199809,0.001041464,0.001510976,0.0002555677,0.0005512005,0.0005366243,0.0005686564,0.00199148],"category_scores_gemma":[0.0002381372,0.0002345353,0.0002763357,0.001640451,0.0003818068,0.0006736587,0.0004067212,0.0008674932,0.002325315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007129629,"about_ca_system_score_gemma":0.0006130817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009075086,"about_ca_topic_score_gemma":0.001682923,"domain_scores_codex":[0.9998963,0.00001449759,0.00001253617,0.00002068886,0.00004042905,0.00001558331],"domain_scores_gemma":[0.999892,0.00002443512,0.00002794749,0.000005637744,0.00003415086,0.0000157596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001249453,0.00006164175,0.0003113661,0.005032251,0.00007063435,0.0002548657,0.00002369398,0.0003364667,0.01265968,0.001908257,0.01558574,0.9636304],"study_design_scores_gemma":[0.00002377373,0.00007114442,0.002084381,0.0006049608,0.00005499245,0.001934246,0.00003039947,0.0001101095,0.004881298,0.001198186,0.9889905,0.00001591239],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004765754,0.9970497,0.0002728285,0.0001798458,0.0001060231,0.000004631785,0.00003641486,0.00001595147,0.00185809],"genre_scores_gemma":[0.002745532,0.9944068,0.00041195,0.0001497941,0.0000717884,0.00000911932,0.0001209692,0.000003304929,0.002080656],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00199148,"threshold_uncertainty_score":0.00666219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0568405841191435,"score_gpt":0.3145426462897602,"score_spread":0.2577020621706167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}