{"id":"W2050299929","doi":"10.4161/cc.10.12.15882","title":"UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation","year":2011,"lang":"en","type":"review","venue":"Cell Cycle","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heritage Medical Research Clinic; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Alberta Cancer Foundation","keywords":"Mdm2; Ubiquitin ligase; Transactivation; Ubiquitin; Biology; Cell biology; Suppressor; DNA ligase; Cancer research; Apoptosis; Biochemistry; Transcription factor; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002997621,0.0005473807,0.001377518,0.0003891229,0.0001154145,0.00004831572,0.0001578786,0.0007804938,0.0001422206],"category_scores_gemma":[0.0002401204,0.0005165117,0.0004322813,0.0003628558,0.00007217469,0.0001165352,0.00007586821,0.000404218,0.0001109348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003551905,"about_ca_system_score_gemma":0.000515742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006362938,"about_ca_topic_score_gemma":0.0000155733,"domain_scores_codex":[0.9975904,0.0001190433,0.0007618224,0.0007546349,0.0002857215,0.0004884299],"domain_scores_gemma":[0.9981655,0.0001879949,0.0006236585,0.0005488999,0.0002061174,0.000267802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006391507,0.0001655259,0.000002257368,0.01619314,0.0001709378,0.00002077474,0.0003587268,7.980412e-8,0.001673071,0.0001248903,0.002825323,0.9784014],"study_design_scores_gemma":[0.001741746,0.0004247875,0.00001533242,0.00579761,0.00139054,0.00007150909,0.00002752988,0.0001980667,0.003203697,0.00007479169,0.9864894,0.0005649611],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000596556,0.9900084,0.001911689,0.00009781617,0.0004187853,0.003272786,0.0004380139,0.000185025,0.003070922],"genre_scores_gemma":[0.0006961107,0.9927443,0.0009651018,0.0002692753,0.000305815,0.0004147602,0.002347468,0.0002153225,0.002041796],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9836641,"threshold_uncertainty_score":0.9997286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0568405841191435,"score_gpt":0.3145426462897602,"score_spread":0.2577020621706167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}