{"id":"W2050318359","doi":"10.1006/cyto.2000.0688","title":"p38 MAP KINASE REGULATES TNF-α PRODUCTION IN HUMAN ASTROCYTES AND MICROGLIA BY MULTIPLE MECHANISMS","year":2000,"lang":"en","type":"article","venue":"Cytokine","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Multiple Sclerosis Society","keywords":"Microglia; Tumor necrosis factor alpha; p38 mitogen-activated protein kinases; Cell biology; Biology; Secretion; Protein kinase A; Astrocyte; Downregulation and upregulation; Lipopolysaccharide; Molecular biology; Kinase; Inflammation; Central nervous system; Immunology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416478,0.000525862,0.000285061,0.0003279643,0.0004509571,0.0005049579,0.0002312219,0.0002861199,0.001503328],"category_scores_gemma":[0.0002402499,0.0002217147,0.00040681,0.0002394169,0.0002431153,0.0004515447,0.0003413394,0.0005334772,0.0006179184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236043,"about_ca_system_score_gemma":0.0003235262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007871122,"about_ca_topic_score_gemma":0.0008965672,"domain_scores_codex":[0.999747,0.00004459625,0.00002037278,0.00003494953,0.00005880073,0.00009438874],"domain_scores_gemma":[0.9999254,0.000008861934,0.00001981094,0.00001089564,0.00002259136,0.00001240821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00176974,0.0001618935,0.00164419,0.0002005807,0.00002604807,0.0005421884,0.0002241337,0.00009843498,0.9891417,0.0002940405,0.0002099461,0.0056871],"study_design_scores_gemma":[0.0001483953,0.0009047096,0.04799557,0.00004663946,0.00009250329,0.002694793,0.0004940084,0.0009230461,0.9404958,0.0007494093,0.005437042,0.00001801646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796943,0.01286551,0.003384698,0.0003373943,0.0001123752,0.00007280253,0.0004221546,0.00004260801,0.003068169],"genre_scores_gemma":[0.9915386,0.00376677,0.00138263,0.00005362013,0.00005550771,0.00009389013,0.000318863,0.000006817048,0.00278329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503328,"threshold_uncertainty_score":0.005029082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01565113019604773,"score_gpt":0.2324529782944193,"score_spread":0.2168018480983716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}