{"id":"W2050319488","doi":"10.1016/j.bcp.2011.02.014","title":"Intramolecular cyclization of N-phenyl N′(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40","year":2011,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale","keywords":"Chemistry; Tubulin; Prodrug; Stereochemistry; Alkylation; Cytotoxic T cell; DNA damage; Carcinogen; DNA; Prohibitin; Biochemistry; Apoptosis; In vitro; Biology; Cell biology; Microtubule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002338313,0.0003329412,0.0001588107,0.0001628479,0.0001417797,0.0001340964,0.0003363624,0.0002546002,0.001833298],"category_scores_gemma":[0.0001692804,0.0001468905,0.0001864608,0.0001143164,0.0002422573,0.000262687,0.0002267926,0.0003560937,0.0003194672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003420524,"about_ca_system_score_gemma":0.0002424838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007398106,"about_ca_topic_score_gemma":0.002227413,"domain_scores_codex":[0.9998978,0.00001723787,0.000006220225,0.0000194578,0.00001771612,0.00004151262],"domain_scores_gemma":[0.9999157,0.00001874169,0.00002848764,0.000008951203,0.00000613339,0.00002200937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002096175,0.000088345,0.0001672201,0.00007900683,0.00001090837,0.0003475385,0.0001392595,0.0003195955,0.9901139,0.001311761,0.0002235172,0.006989494],"study_design_scores_gemma":[0.00004206619,0.0008304943,0.001739282,0.000007083569,0.00001150966,0.0003781294,0.00002684982,0.0006347627,0.992203,0.0001212445,0.003993343,0.00001217549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857636,0.001028226,0.004538022,0.0001135295,0.00004470974,0.00004244352,0.0000883561,0.0001522619,0.008228851],"genre_scores_gemma":[0.9958884,0.0004085525,0.001095517,0.00002961738,0.000008926041,0.00001889787,0.00006385822,0.0000153642,0.00247093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001833298,"threshold_uncertainty_score":0.00613296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02163962935570129,"score_gpt":0.2841968344224863,"score_spread":0.262557205066785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}