{"id":"W2050342642","doi":"10.1074/jbc.m505019200","title":"Hepatitis C Virus NS2/3 Processing Is Required for NS3 Stability and Viral RNA Replication","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"NS3; Virology; Hepatitis C virus; Viral replication; NS2-3 protease; Replication (statistics); RNA; Hepatitis B virus PRE beta; RNA-dependent RNA polymerase; Virus; Biology; Chemistry; Hepatitis B virus DNA polymerase; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916167,0.0003470881,0.0002886048,0.0001291753,0.0002904997,0.0004735678,0.000143791,0.0002595242,0.0009908137],"category_scores_gemma":[0.0002297285,0.000154698,0.0003292764,0.0001216605,0.00022215,0.0002333282,0.0002131998,0.0003044792,0.0007857857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004662513,"about_ca_system_score_gemma":0.0004183179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001367891,"about_ca_topic_score_gemma":0.0009653585,"domain_scores_codex":[0.9997991,0.0000388417,0.00002643429,0.00003889782,0.00005188046,0.00004495098],"domain_scores_gemma":[0.999797,0.00002608755,0.00005857291,0.00003039882,0.00002951158,0.00005839761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001284786,0.00001325358,0.0003035681,0.00002048536,0.000003833535,0.00006831633,0.00001033634,0.0000392888,0.9988166,0.00003643127,0.0000171136,0.0005423367],"study_design_scores_gemma":[0.00001441039,0.0001296165,0.01804212,0.000006299552,0.00001011504,0.0005152698,0.00002929331,0.001199777,0.9783874,0.00007028359,0.001587792,0.000007570472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952782,0.001328624,0.002053098,0.00005851518,0.00002017592,0.00001598432,0.0002798195,0.00008343894,0.000882122],"genre_scores_gemma":[0.996996,0.0003285545,0.001280552,0.00002750446,0.000007470469,0.0000096236,0.0005310017,0.00002538164,0.0007939013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001367891,"threshold_uncertainty_score":0.003382921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08517107222394993,"score_gpt":0.3673960125245797,"score_spread":0.2822249403006297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}