{"id":"W2050342642","doi":"10.1074/jbc.m505019200","title":"Hepatitis C Virus NS2/3 Processing Is Required for NS3 Stability and Viral RNA Replication","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"NS3; Virology; Hepatitis C virus; Viral replication; NS2-3 protease; Replication (statistics); RNA; Hepatitis B virus PRE beta; RNA-dependent RNA polymerase; Virus; Biology; Chemistry; Hepatitis B virus DNA polymerase; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007663859,0.0001152537,0.0003340433,0.0000253981,0.00007609349,0.0000300954,0.0001143208,0.0002085293,0.0003058781],"category_scores_gemma":[0.001549069,0.00008054838,0.0001170112,0.00008659913,0.0001730487,0.0001242745,0.00004428279,0.000311639,0.000002958282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722754,"about_ca_system_score_gemma":0.0001448426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001535797,"about_ca_topic_score_gemma":0.000002959521,"domain_scores_codex":[0.9986866,0.00003061553,0.0005368313,0.0002590058,0.0002570459,0.0002298696],"domain_scores_gemma":[0.9987676,0.0001081304,0.0002694374,0.0002246867,0.0004014931,0.0002287172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004214285,0.0001405952,0.0418427,0.0001541837,0.00002213828,0.00001012104,0.00006451767,1.447378e-7,0.852314,0.000001887634,0.0007328592,0.1042954],"study_design_scores_gemma":[0.001101008,0.0004824747,0.0191814,0.00009388673,0.00002820036,0.0001259489,0.00002622645,0.0005567576,0.9632846,0.0002532235,0.01475733,0.0001089469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942816,0.0009243268,0.0005631741,0.002830209,0.00001387942,0.0001884208,0.00003289566,0.00001706309,0.001148441],"genre_scores_gemma":[0.9919359,0.001261411,0.005694045,0.0004159458,0.0005330148,0.00001330164,0.00001185229,0.000009424058,0.0001251023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1109706,"threshold_uncertainty_score":0.3349151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08517107222394993,"score_gpt":0.3673960125245797,"score_spread":0.2822249403006297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}