{"id":"W2050347424","doi":"10.1016/j.neuron.2007.07.041","title":"Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action","year":2007,"lang":"en","type":"article","venue":"Neuron","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":346,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Citalopram; Behavioural despair test; Antidepressant; Agonist; Serotonin; Internal medicine; 5-HT receptor; Endocrinology; Pharmacology; Hippocampus; Receptor; Hippocampal formation; Psychology; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115917,0.0003739417,0.0003965028,0.0002074261,0.0001190074,0.0001942115,0.0002087067,0.0004233293,0.00385909],"category_scores_gemma":[0.0001685438,0.0001656008,0.000249417,0.00007274021,0.000121784,0.0001659562,0.000148079,0.0003700481,0.0009323437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002556576,"about_ca_system_score_gemma":0.000176889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000494927,"about_ca_topic_score_gemma":0.001329536,"domain_scores_codex":[0.9999496,0.00001067675,0.000004361243,0.000007938383,0.00001442197,0.00001293509],"domain_scores_gemma":[0.9998958,0.00002679004,0.00003134218,0.000005651811,0.00002067277,0.00001975322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003088397,0.0001191333,0.001837021,0.0008357508,0.00007091514,0.0007047398,0.00003696572,0.0001507713,0.8850905,0.002176815,0.001256363,0.1046326],"study_design_scores_gemma":[0.0006061342,0.009926561,0.09296004,0.0002183032,0.0003456806,0.007690616,0.0001748531,0.000919204,0.83332,0.001375377,0.05241246,0.00005074601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8342347,0.1375425,0.00923554,0.0005114411,0.0003089026,0.0003753059,0.001448636,0.0003761816,0.01596672],"genre_scores_gemma":[0.9601443,0.0229306,0.004822798,0.0004145149,0.0001045678,0.0001295905,0.000626837,0.00001963365,0.01080708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00385909,"threshold_uncertainty_score":0.01291001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05520665424521203,"score_gpt":0.294406695620087,"score_spread":0.2392000413748749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}