{"id":"W2050348933","doi":"10.1371/journal.pone.0041865","title":"Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal; Montreal Clinical Research Institute","funders":"Institute of Nutrition, Metabolism and Diabetes; Canadian Institutes of Health Research; State University of New York; SUNY Downstate Medical Center; Heart and Stroke Foundation of Canada","keywords":"PCSK9; LDL receptor; Biology; Endocrinology; Kexin; Internal medicine; Proprotein convertase; Annexin A2; Cholesterol; Lipoprotein; Annexin; Molecular biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003931042,0.0001078486,0.0003133915,0.00003373785,0.00006313881,0.00000582872,0.00007602699,0.00008488283,0.0001265038],"category_scores_gemma":[0.0001998378,0.0000703786,0.0001801428,0.0002172272,0.00003106979,0.0001120892,0.00003421501,0.0002243448,0.0000515334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008053376,"about_ca_system_score_gemma":0.00007243355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000177213,"about_ca_topic_score_gemma":0.000009914369,"domain_scores_codex":[0.9986168,0.00009142834,0.0002423732,0.0001354732,0.0006665132,0.0002473812],"domain_scores_gemma":[0.9991184,0.00002348245,0.0001036731,0.0005043042,0.0001308219,0.0001193145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001947588,0.002849565,0.05969384,0.001327935,0.001061495,0.000001333996,0.002219529,4.274973e-8,0.9002909,0.0001764195,0.001153786,0.03103037],"study_design_scores_gemma":[0.00125425,0.000210042,0.08375451,0.0006823231,0.0005190282,0.000008298074,0.0001802634,0.0000746227,0.9123346,0.00002201797,0.0008200301,0.0001399669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956125,0.001623115,0.000009460767,0.00135798,0.000223856,0.0007757505,0.000007368659,0.00003036909,0.000359596],"genre_scores_gemma":[0.9965001,0.00005010964,0.001550128,0.0005048676,0.0007777116,0.00004059301,0.00001330546,0.00002120537,0.0005420088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0308904,"threshold_uncertainty_score":0.2869956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04892088453730945,"score_gpt":0.24928329526505,"score_spread":0.2003624107277406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}