{"id":"W2050372002","doi":"10.1016/j.jmb.2008.09.024","title":"Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Canada Research Chairs; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Epitope; Gp41; Paratope; Monoclonal antibody; Chemistry; V3 loop; Peptide; Linear epitope; Antibody; Neutralization; Antigen; Epitope mapping; Biophysics; Virology; Biochemistry; Biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192515,0.0002142619,0.000184975,0.0001004364,0.0002884095,0.0003274691,0.0003873166,0.0002477067,0.002185143],"category_scores_gemma":[0.000151687,0.0001308967,0.0001804368,0.00007887962,0.000194162,0.0002868117,0.0001372949,0.0005047606,0.0002438693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005274261,"about_ca_system_score_gemma":0.0002835607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003455569,"about_ca_topic_score_gemma":0.002855556,"domain_scores_codex":[0.9999503,0.000006728541,0.00000216763,0.000008650623,0.00001207468,0.00002014546],"domain_scores_gemma":[0.9999511,0.00001454228,0.00001149407,0.000003368526,0.00000590541,0.00001359991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00106582,0.0001861979,0.004152204,0.0001366756,0.00004080994,0.0007785702,0.0002153327,0.006791611,0.9692293,0.004993648,0.0007728072,0.01163703],"study_design_scores_gemma":[0.0003485995,0.001393434,0.05111919,0.00007945287,0.0001689973,0.001729332,0.000629061,0.08628177,0.8370309,0.003073945,0.01803003,0.0001152236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952536,0.0007646221,0.002340548,0.0001307009,0.00001891398,0.000008342131,0.0001064822,0.00003665762,0.001340224],"genre_scores_gemma":[0.9984273,0.0001806952,0.0006316557,0.00006694536,0.000004377058,0.000002188735,0.000164939,0.000003197713,0.0005187226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003455569,"threshold_uncertainty_score":0.007310033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02410645144481809,"score_gpt":0.2901929490526841,"score_spread":0.266086497607866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}