{"id":"W2050384227","doi":"10.1007/s00216-015-8574-9","title":"A simple method for the subnanomolar quantitation of seven ophthalmic drugs in the rabbit eye","year":2015,"lang":"en","type":"article","venue":"Analytical and Bioanalytical Chemistry","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Canada Research Chairs","keywords":"Chromatography; Triamcinolone acetonide; Chemistry; Detection limit; Cornea; Tandem mass spectrometry; Pharmacokinetics; Mass spectrometry; Pharmacology; Ophthalmology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002910814,0.0002232493,0.0003967554,0.00003888019,0.0001267307,0.00003453893,0.0005236253,0.0003291284,0.0001666239],"category_scores_gemma":[0.001149531,0.0001197712,0.0001976675,0.0004524384,0.000515776,0.0000735267,0.0001212776,0.000824778,0.000008138164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005291138,"about_ca_system_score_gemma":0.00008143431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004024837,"about_ca_topic_score_gemma":0.000006026552,"domain_scores_codex":[0.9981112,0.0003831882,0.000453518,0.0003418048,0.0002903991,0.0004199202],"domain_scores_gemma":[0.9937822,0.005498754,0.0001101494,0.0002068778,0.0001610349,0.0002409317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.02202706,0.009233866,0.09910318,0.003533745,0.006130255,0.0005602743,0.005607769,0.004202032,0.5885228,0.07706244,0.09620728,0.08780931],"study_design_scores_gemma":[0.006458195,0.0006755551,0.007044911,0.00002902356,0.001849693,0.00009951839,0.00250693,0.8293468,0.05954686,0.02641442,0.06529291,0.0007351367],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799609,0.001675199,0.0009048778,0.01337746,0.0001138002,0.0006608644,0.00006814596,0.00003155529,0.003207236],"genre_scores_gemma":[0.9976031,0.00004556065,0.0003050038,0.001458038,0.0001662222,0.00004389619,0.00002605641,0.00001001002,0.0003420983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8251448,"threshold_uncertainty_score":0.4884129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1418629155458047,"score_gpt":0.4829834204127682,"score_spread":0.3411205048669635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}