{"id":"W2050384698","doi":"10.1210/en.2010-1170","title":"Modulation of PC1/3 Activity by Self-Interaction and Substrate Binding","year":2011,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; University of British Columbia","funders":"National Institute on Drug Abuse; National Institutes of Health; Canadian Institutes of Health Research; Institut de Recherche Clinique De Montréal","keywords":"Prohormone; Biochemistry; Chinese hamster ovary cell; Prohormone convertase; Peptide; Chemistry; Proopiomelanocortin; Proinsulin; Enzyme; Glycosylation; Biology; Hormone; Receptor; Endocrinology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009417767,0.0002692701,0.0001731977,0.0000981929,0.000126919,0.0003340135,0.0002102456,0.0001601145,0.0009566111],"category_scores_gemma":[0.0001320577,0.00008958181,0.0001708832,0.0001297235,0.0001724523,0.0001525273,0.000194752,0.0003841357,0.0003228324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002693587,"about_ca_system_score_gemma":0.0001364979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004653621,"about_ca_topic_score_gemma":0.0004737938,"domain_scores_codex":[0.9998604,0.00001976272,0.00001148731,0.00003321256,0.00002837103,0.0000467394],"domain_scores_gemma":[0.9999143,0.00001993194,0.00002223353,0.00001097669,0.000009246507,0.00002318278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000138156,0.00003497047,0.0001389121,0.00002266129,0.000003198088,0.00001744824,0.00001158828,0.00002494269,0.9985598,0.00004393618,0.00002270027,0.0009816707],"study_design_scores_gemma":[0.000009055505,0.00008570519,0.003029386,0.000002238195,0.000006689949,0.00006230121,0.00000901683,0.0005970348,0.9953638,0.00002375417,0.0008080361,0.000003000743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969777,0.001125271,0.001158079,0.00003485215,0.0000143412,0.0000136079,0.00008782376,0.00003705533,0.0005512476],"genre_scores_gemma":[0.9968557,0.0007653025,0.001085861,0.00003774173,0.00001008358,0.00002638066,0.0002695573,0.0000167325,0.0009325823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009566111,"threshold_uncertainty_score":0.003200233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806207722641803,"score_gpt":0.2301370979317605,"score_spread":0.2120750207053425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}