{"id":"W2050397606","doi":"10.1073/pnas.1102715108","title":"GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":412,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Insulitis; Islet; Beta cell; Immune system; Depolarization; Cell; Cell biology; Endocrinology; Internal medicine; Diabetes mellitus; Biology; Cancer research; Chemistry; Pharmacology; Immunology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349154,0.0002899004,0.0002640628,0.0002719425,0.0001079762,0.0002864747,0.0001386287,0.0002130118,0.0007257073],"category_scores_gemma":[0.00009024863,0.00007598428,0.0001921181,0.0001259315,0.0002253074,0.0001292067,0.0001687868,0.0005829008,0.0002340093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001557205,"about_ca_system_score_gemma":0.0002122742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003344389,"about_ca_topic_score_gemma":0.0005972062,"domain_scores_codex":[0.999935,0.00001539225,0.000005981949,0.000008487652,0.00001464392,0.00002051014],"domain_scores_gemma":[0.9999489,0.000006541317,0.00001377587,0.000006025822,0.000006509095,0.00001823473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008027469,0.0001031389,0.0005615619,0.0002881595,0.00002659443,0.0002085909,0.00003258212,0.0001320578,0.9522308,0.0005013801,0.0002355672,0.04487692],"study_design_scores_gemma":[0.0002990882,0.004247882,0.02739599,0.0001042879,0.0001726755,0.001730946,0.0001571482,0.0006072199,0.9377327,0.0007807894,0.0267539,0.00001720134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639146,0.02619343,0.002741269,0.0008649068,0.0001822982,0.00002479275,0.0001335234,0.0001658233,0.005779415],"genre_scores_gemma":[0.9765486,0.01853986,0.002124866,0.0003059621,0.0001093793,0.00001620594,0.0001166037,0.0000293469,0.002209126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007257073,"threshold_uncertainty_score":0.002427757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03788914363063957,"score_gpt":0.2680254166071645,"score_spread":0.2301362729765249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}