{"id":"W2050440877","doi":"10.1053/j.ajkd.2014.09.015","title":"Effect of CKD and Dialysis Modality on Exposure to Drugs Cleared by Nonrenal Mechanisms","year":2014,"lang":"en","type":"article","venue":"American Journal of Kidney Diseases","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Lawson Health Research Institute; American Society of Nephrology","keywords":"Medicine; Clearance; Dialysis; Modality (human–computer interaction); Kidney disease; Metabolic clearance rate; Renal function; Intensive care medicine; Internal medicine; Pharmacology; Urology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001136083,0.0002454605,0.0007286116,0.0001801269,0.0001032842,0.00001716316,0.0002976266,0.00006252902,0.0002054699],"category_scores_gemma":[0.001004731,0.0001944187,0.0002463379,0.0002614618,0.0002714488,0.00006494553,0.00007142265,0.0003273716,0.00001018325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002290459,"about_ca_system_score_gemma":0.0001185762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001834298,"about_ca_topic_score_gemma":1.697646e-7,"domain_scores_codex":[0.9970153,0.001610466,0.0004983193,0.0002275719,0.0003423248,0.000306025],"domain_scores_gemma":[0.9964204,0.0008063763,0.000529951,0.000176634,0.0001418481,0.001924719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01020413,0.001133972,0.01980038,0.0001561631,0.001283106,0.00002726923,0.001113232,0.00096114,0.3331244,0.0003663955,0.02607357,0.6057562],"study_design_scores_gemma":[0.01384566,0.02154675,0.01565676,0.000186186,0.005824815,0.00004893924,0.0004566321,0.001575813,0.8299214,0.001857477,0.1079194,0.001160094],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955946,0.0004930543,0.0006166135,0.001941429,0.0004636477,0.0001668971,0.0004227876,0.00001286032,0.0002881002],"genre_scores_gemma":[0.9916356,0.0003005522,0.0001944675,0.007537305,0.0002446455,0.000009492414,0.00001083584,0.00002393921,0.00004312704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6045961,"threshold_uncertainty_score":0.7928165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281538090334569,"score_gpt":0.3623033779102713,"score_spread":0.3494879970069256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}