{"id":"W2050519187","doi":"10.1110/ps.4170102","title":"Importance of secondary structural specificity determinants in protein folding: Insertion of a native β‐sheet sequence into an α‐helical coiled‐coil","year":2002,"lang":"en","type":"article","venue":"Protein Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Fondation pour la Recherche Médicale","keywords":"Beta sheet; Coiled coil; Random coil; Protein secondary structure; Protein folding; Protein engineering; Protein structure; Structural motif; Protein tertiary structure; Crystallography; Chemistry; Biophysics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002167293,0.0002065501,0.0001830556,0.00006782236,0.0001148639,0.0002053095,0.0001139276,0.0002176284,0.0004193792],"category_scores_gemma":[0.0002037139,0.0001252873,0.0001471063,0.00005336172,0.000299933,0.0001662252,0.0001513899,0.0002710375,0.000166042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002093319,"about_ca_system_score_gemma":0.0001979717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003981398,"about_ca_topic_score_gemma":0.0004832945,"domain_scores_codex":[0.9998932,0.00003049908,0.000009261385,0.00002279154,0.0000250444,0.00001914282],"domain_scores_gemma":[0.9998059,0.00005913842,0.00005209847,0.00002077103,0.00001770921,0.0000444531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004682369,0.00001005144,0.0003158661,0.00001303578,0.000001735997,0.00004485461,0.00001085335,0.000234497,0.9987161,0.00007666832,0.000003417379,0.0005260367],"study_design_scores_gemma":[0.00001413848,0.0003799734,0.004844457,0.000005749257,0.00001676004,0.0004687143,0.00002114062,0.00264558,0.9908909,0.00007996052,0.0006272694,0.000005349531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958369,0.0001604284,0.003443598,0.00002437921,0.000005273052,0.0000202593,0.00002106485,0.00002192492,0.0004663084],"genre_scores_gemma":[0.9978765,0.00006489034,0.001761883,0.00001811166,0.000002470729,0.000007174192,0.00003768875,0.000005254616,0.0002260165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004193792,"threshold_uncertainty_score":0.001518786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02031461582441833,"score_gpt":0.2877433276005816,"score_spread":0.2674287117761632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}