{"id":"W2050527519","doi":"10.1016/j.jchromb.2010.08.034","title":"A general HPLC–UV method for the quantitative determination of curcumin analogues containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore in rat biomatrices","year":2010,"lang":"en","type":"article","venue":"Journal of Chromatography B","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Chromatography; Ammonium acetate; High-performance liquid chromatography; Pharmacophore; Acetonitrile; Pharmacokinetics; Stereochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001020987,0.002695287,0.0008737248,0.001887402,0.0009813303,0.0003719859,0.00130091,0.001035329,0.007430492],"category_scores_gemma":[0.0008584661,0.001340861,0.0006927529,0.0007888295,0.0007808384,0.0007602891,0.0005389431,0.002788165,0.006769867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008326176,"about_ca_system_score_gemma":0.002036977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067025,"about_ca_topic_score_gemma":0.003768185,"domain_scores_codex":[0.9992936,0.0001472242,0.00006536934,0.0002242543,0.0001768764,0.0000926616],"domain_scores_gemma":[0.9992375,0.0002435026,0.00008698016,0.0001571679,0.000156349,0.00011849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002007658,0.0001831781,0.0001520833,0.0002480629,0.00002846762,0.00008752977,0.00003410297,0.0001730579,0.9833012,0.0005097393,0.001133326,0.01394849],"study_design_scores_gemma":[0.0001126802,0.0007325048,0.002333982,0.0000438852,0.00009764812,0.001331674,0.00002023435,0.001937175,0.9746152,0.0005384407,0.0181646,0.00007217417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.08078913,0.005880579,0.8895345,0.0006910429,0.0005747526,0.001818415,0.002368478,0.01049359,0.007849425],"genre_scores_gemma":[0.1921072,0.009692,0.7461587,0.001602527,0.0003673171,0.007122052,0.008024842,0.001015347,0.03391005],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007430492,"threshold_uncertainty_score":0.02485746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523063725260684,"score_gpt":0.3444494794913718,"score_spread":0.329218842238765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}