{"id":"W2050593873","doi":"10.1016/j.chembiol.2013.10.008","title":"Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein","year":2013,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute on Aging; Canadian Institutes of Health Research; U.S. Public Health Service; Memorial Sloan-Kettering Cancer Center; Susan G. Komen; National Cancer Institute; National Institutes of Health; National Center for Research Resources; Geoffrey Beene Cancer Research Center","keywords":"Allosteric regulation; Hsp70; Biology; Hsp90; Computational biology; Cell biology; Chemical biology; Small molecule; Biochemistry; Heat shock protein; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023314,0.0001508965,0.0002746861,0.00004058016,0.00003109057,0.00000554441,0.0002557351,0.000348319,0.0002812236],"category_scores_gemma":[0.000145036,0.0001353652,0.00008838023,0.00009773357,0.0002954873,0.000006282109,0.00009713371,0.0001169136,0.000004452105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000174896,"about_ca_system_score_gemma":0.00008330186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008638894,"about_ca_topic_score_gemma":0.00000255735,"domain_scores_codex":[0.9984188,0.0001225159,0.0007111152,0.00037551,0.0001410342,0.0002310305],"domain_scores_gemma":[0.9985817,0.00001153945,0.000348293,0.0006514199,0.0003304488,0.0000766037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009340176,0.0002486287,0.0004012192,0.0002038129,0.00004138496,5.051057e-7,0.00002974552,0.000001348533,0.997851,0.00007407776,0.00004279373,0.001012093],"study_design_scores_gemma":[0.0003246781,0.0006834623,0.0006697782,0.00004175871,0.000007752179,0.000004249252,0.00002498897,0.00004747008,0.9970201,0.0009602281,0.0000997508,0.0001157811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984386,0.0001484806,0.00009074885,0.00009468431,0.000009424847,0.0005534008,0.00007967777,0.000007061427,0.0005778988],"genre_scores_gemma":[0.9987998,0.00002998864,0.0002090429,0.00003761165,0.00005303337,0.0001425848,0.0003968933,0.00001878699,0.0003122405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008963121,"threshold_uncertainty_score":0.5520035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194706903487088,"score_gpt":0.3335376259156816,"score_spread":0.3115905568808107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}