{"id":"W2050608866","doi":"10.1016/s0049-3848(00)00263-2","title":"Mutation of Any Site of N-Linked Glycosylation Accelerates the In Vivo Clearance of Recombinant Rabbit Antithrombin","year":2000,"lang":"en","type":"article","venue":"Thrombosis Research","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Glycosylation; Recombinant DNA; Chinese hamster ovary cell; Molecular biology; Glycan; Biochemistry; In vivo; Chemistry; Transfection; Antithrombin; Biology; Glycoprotein; Gene; Heparin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002000233,0.0001376288,0.0005944789,0.0003898502,0.00008335352,0.00001285769,0.0001980719,0.0001469555,0.002299855],"category_scores_gemma":[0.000180357,0.0001048543,0.0001124795,0.001567536,0.0003690717,0.0001693803,0.00004901798,0.0003397253,0.00003715115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005624896,"about_ca_system_score_gemma":0.0001429471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00136156,"about_ca_topic_score_gemma":0.0001230609,"domain_scores_codex":[0.9972793,0.0004448242,0.0007653529,0.0002792421,0.000901251,0.0003300428],"domain_scores_gemma":[0.9983186,0.00032418,0.0002013659,0.0005121554,0.0005789826,0.00006474705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006074926,0.001214013,0.01778842,0.0003422485,0.00009689305,0.000002632601,0.002440825,0.0002627861,0.9660745,0.002668486,0.0002646787,0.008237091],"study_design_scores_gemma":[0.0019106,0.0007669266,0.5042148,0.0004596117,0.00002937282,0.000003328934,0.0003146287,0.005609088,0.4843619,0.002177489,0.00007142963,0.00008085835],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950811,0.000196234,0.00002958426,0.000775138,0.00006055535,0.0008222477,0.000009586761,0.00001714077,0.003008462],"genre_scores_gemma":[0.9983169,0.0008878744,0.000368234,0.00002428701,0.00002266327,0.00002342696,0.00001635897,0.00002502732,0.0003152555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4864264,"threshold_uncertainty_score":0.9986122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1013100950820457,"score_gpt":0.3882712758386497,"score_spread":0.286961180756604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}