{"id":"W2050663885","doi":"10.1155/2012/292730","title":"<i>In Vivo</i>Clearance of Alpha-1 Acid Glycoprotein Is Influenced by the Extent of Its N-Linked Glycosylation and by Its Interaction with the Vessel Wall","year":2012,"lang":"en","type":"article","venue":"Journal of Biomedicine and Biotechnology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; McMaster University","keywords":"PNGase F; Pichia pastoris; Glycoprotein; Glycosylation; In vivo; Glycan; Neuraminidase; Chemistry; Biochemistry; Hyaluronidase; Hyaluronic acid; Orosomucoid; Recombinant DNA; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000498352,0.0001105921,0.0002088912,0.0001377367,0.00004439113,0.000006285394,0.0001675622,0.0002071774,0.00001884152],"category_scores_gemma":[0.00008664664,0.00005746669,0.00002992042,0.0002643813,0.0003162211,0.00002706243,0.00005957437,0.0002534174,5.058035e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001073478,"about_ca_system_score_gemma":0.00003007092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003172395,"about_ca_topic_score_gemma":0.000008571587,"domain_scores_codex":[0.9990642,0.00006301243,0.0003582512,0.0001225807,0.0002156732,0.0001762585],"domain_scores_gemma":[0.9992018,0.00002353696,0.0003989626,0.0001529998,0.0001718111,0.00005092856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000576648,0.0000742416,0.000387049,0.00004347527,0.00004526085,0.000001116655,0.0001294826,8.619278e-7,0.9888576,0.00002452401,0.00266155,0.007198177],"study_design_scores_gemma":[0.001207902,0.001363567,0.001222537,0.00007669492,0.00001916207,0.0001420037,0.0002664567,0.00008403608,0.9370101,0.00001088224,0.0585354,0.00006124959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693148,0.01361508,0.0003799557,0.01637037,0.00004352941,0.0002416395,0.00001241323,0.000001963002,0.00002024241],"genre_scores_gemma":[0.9947953,0.004576467,0.00006918119,0.0003932412,0.00005199856,0.000005765001,0.000003390166,0.000007343379,0.00009729857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05587385,"threshold_uncertainty_score":0.2343424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00818665092265222,"score_gpt":0.2701408606103183,"score_spread":0.2619542096876661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}