{"id":"W2050663885","doi":"10.1155/2012/292730","title":"<i>In Vivo</i>Clearance of Alpha-1 Acid Glycoprotein Is Influenced by the Extent of Its N-Linked Glycosylation and by Its Interaction with the Vessel Wall","year":2012,"lang":"en","type":"article","venue":"Journal of Biomedicine and Biotechnology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; McMaster University","keywords":"PNGase F; Pichia pastoris; Glycoprotein; Glycosylation; In vivo; Glycan; Neuraminidase; Chemistry; Biochemistry; Hyaluronidase; Hyaluronic acid; Orosomucoid; Recombinant DNA; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000343954,0.0003431215,0.000294621,0.0001532098,0.0001269845,0.0006521058,0.0002224416,0.0003841778,0.0008134953],"category_scores_gemma":[0.0003664723,0.0001717719,0.0002187066,0.0001423788,0.0003511203,0.0004303125,0.00009588172,0.0006787213,0.0003737914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005349906,"about_ca_system_score_gemma":0.0002555148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005082188,"about_ca_topic_score_gemma":0.000290506,"domain_scores_codex":[0.9997497,0.00006129896,0.00001450804,0.00007091151,0.00004410326,0.00005945755],"domain_scores_gemma":[0.9997,0.00005772811,0.0001373016,0.00003986434,0.00002929033,0.00003586724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001652164,0.0000602807,0.002369792,0.00006505093,0.00002150644,0.0001004162,0.00002459614,0.0001874839,0.9900751,0.0003027318,0.0002107526,0.004930174],"study_design_scores_gemma":[0.00003424634,0.0007136554,0.01744748,0.000008245407,0.00004010108,0.0006839497,0.000019297,0.002228687,0.9765279,0.0001839146,0.002102785,0.000009899339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830425,0.003742009,0.0104245,0.000258926,0.00004852287,0.00002571653,0.0003360256,0.0001849166,0.001936935],"genre_scores_gemma":[0.9935192,0.001557346,0.002143525,0.0001872954,0.00005241692,0.00003347473,0.0006448668,0.00006256194,0.001799261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008134953,"threshold_uncertainty_score":0.003881693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00818665092265222,"score_gpt":0.2701408606103183,"score_spread":0.2619542096876661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}