{"id":"W2050711538","doi":"10.1042/bsr20080111","title":"The mechanism of specific binding of free cholesterol by the steroidogenic acute regulatory protein: evidence for a role of the C-terminal α-helix in the gating of the binding site","year":2008,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Steroidogenic acute regulatory protein; Helix (gastropod); Binding site; Biochemistry; Cholesterol; Mutation; Salt bridge; Mutagenesis; Cholesterol side-chain cleavage enzyme; Biology; Chemistry; Mutant; Biophysics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483552,0.0003224027,0.0002688894,0.00009402855,0.0001727398,0.0002210814,0.0004999657,0.0003216165,0.0005769278],"category_scores_gemma":[0.0002292395,0.0001167767,0.0002599249,0.00009226985,0.0005365008,0.0003317818,0.0001853903,0.0004720577,0.0003188626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003137223,"about_ca_system_score_gemma":0.0001973545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005301445,"about_ca_topic_score_gemma":0.000306596,"domain_scores_codex":[0.9999011,0.00002117209,0.000007858223,0.00002563028,0.00002818753,0.00001610193],"domain_scores_gemma":[0.9998671,0.00003707787,0.00003835132,0.0000147707,0.00001863207,0.00002411359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002256029,0.00004358064,0.001132328,0.00009747362,0.00001491628,0.0003522202,0.00005228979,0.001850466,0.9930841,0.0007870049,0.00005498103,0.002305005],"study_design_scores_gemma":[0.00004686971,0.000274989,0.002737813,0.00001448125,0.00003008448,0.0007038607,0.00006274361,0.01675145,0.9770463,0.0005039874,0.001802141,0.00002542749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906059,0.0007557365,0.007801343,0.0001277704,0.00002155397,0.0000276645,0.00006248774,0.00003961446,0.0005579206],"genre_scores_gemma":[0.9937449,0.0005832933,0.004948298,0.00005790676,0.000008292154,0.00001767463,0.0001359711,0.000009825302,0.00049384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005769278,"threshold_uncertainty_score":0.002276301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04500907059737038,"score_gpt":0.2831325746247844,"score_spread":0.238123504027414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}