{"id":"W2050714175","doi":"10.1074/jbc.m705524200","title":"Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval","funders":"","keywords":"Ligand (biochemistry); Androgen receptor; Chemistry; Helix (gastropod); Stereochemistry; Domain (mathematical analysis); Steroid; Androgen; Receptor; Combinatorial chemistry; Biophysics; Biochemistry; Biology; Internal medicine; Medicine; Prostate cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045394,0.0001988983,0.0002949159,0.00002842362,0.0001438745,0.00002745043,0.0002653594,0.0003217527,0.00001509938],"category_scores_gemma":[0.00007463025,0.0001145928,0.0001618466,0.0001233507,0.0001639636,0.000009316565,0.00008406852,0.0002744914,4.042126e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003545809,"about_ca_system_score_gemma":0.00007021616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001294986,"about_ca_topic_score_gemma":8.781994e-7,"domain_scores_codex":[0.9987697,0.00005516108,0.0005033003,0.0002050314,0.0002219783,0.0002448371],"domain_scores_gemma":[0.9989389,0.00003125573,0.000603487,0.0001424476,0.000168366,0.0001155367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000676366,0.0000508732,0.01252005,0.0000308761,0.0001465973,0.00001048272,0.00009497997,0.000008509843,0.9863217,0.000004300237,0.00001213214,0.000123157],"study_design_scores_gemma":[0.001126825,0.0005000199,0.02037701,0.00009774358,0.00002776025,0.0002148578,0.00007710233,0.00000673352,0.9773301,0.00001649782,0.000076873,0.0001483983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991467,0.0002002512,0.0002624393,0.00007127052,0.0000687996,0.0001608434,0.00001828827,0.00001008548,0.00006132133],"genre_scores_gemma":[0.9989044,0.00003921827,0.0004800342,0.00003496437,0.0003119002,0.000002250931,0.0001332999,0.00001449817,0.00007943419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0089915,"threshold_uncertainty_score":0.4672959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442287132888901,"score_gpt":0.2351560818732949,"score_spread":0.2207332105444059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}