{"id":"W2050716689","doi":"10.1016/j.coviro.2013.06.006","title":"Selective recognition of viral promoters by host cell transcription complexes: challenges and opportunities to control latency","year":2013,"lang":"en","type":"review","venue":"Current Opinion in Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; National Science Council","keywords":"Promoter; Biology; Transcription (linguistics); RNA polymerase II; Human immunodeficiency virus (HIV); Virus latency; Transcription factor; Virology; Computational biology; Activator (genetics); Transcription factor II D; Genetics; Gene; Viral replication; Virus; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002382195,0.0003693977,0.001288902,0.0004232214,0.00005617197,0.000007226707,0.0001608475,0.0004649122,0.0001474913],"category_scores_gemma":[0.0000231107,0.0003062172,0.0001461469,0.00005615811,0.0002743619,0.00007885469,0.0000431738,0.0005208147,0.0003086815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008643463,"about_ca_system_score_gemma":0.0001173888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004116374,"about_ca_topic_score_gemma":0.000007187791,"domain_scores_codex":[0.9973003,0.001110056,0.0006109018,0.0004903176,0.00004589482,0.0004424794],"domain_scores_gemma":[0.9992335,0.0002053608,0.0002483004,0.0001726109,0.00007700128,0.00006323212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000998201,0.0004914955,0.000005521373,0.007407334,0.0001921424,6.82199e-7,0.0006168061,2.927392e-8,0.001061781,0.00008570965,0.002372981,0.9876657],"study_design_scores_gemma":[0.002141954,0.001901269,0.0001393681,0.002830212,0.0001395031,0.00002482883,0.0001036797,4.603669e-7,0.00008807343,0.000101689,0.9922253,0.0003036522],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007291347,0.9942466,0.00002987868,0.0001784456,0.001063601,0.00211021,0.001471631,0.00002200658,0.0001484857],"genre_scores_gemma":[0.002713648,0.9930616,0.000007812396,0.00001005756,0.00003527225,0.0009212476,0.003165647,0.00002434761,0.00006034333],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9898523,"threshold_uncertainty_score":0.999939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.175295296050739,"score_gpt":0.3522381320316116,"score_spread":0.1769428359808726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}