{"id":"W2050718166","doi":"10.3892/or.2013.2844","title":"Extract of Bryophyllum laetivirens reverses etoposide resistance in human lung A549 cancer cells by downregulation of NF-κB","year":2013,"lang":"en","type":"article","venue":"Oncology Reports","topic":"Ginseng Biological Effects and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Division of Chemistry; Office of the Higher Education Commission; National Research Foundation","keywords":"Downregulation and upregulation; Etoposide; Apoptosis; Cancer research; Cancer cell; Biology; A549 cell; Lung cancer; Multiple drug resistance; Cancer; Pharmacology; Drug resistance; Medicine; Chemotherapy; Internal medicine; Biochemistry; Microbiology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009631875,0.0003485984,0.0004870679,0.0003274604,0.0001657201,0.0001707228,0.0001601906,0.0001636817,0.001157371],"category_scores_gemma":[0.00008865746,0.000118063,0.0004311161,0.0002347076,0.0001273623,0.0001998695,0.0001665338,0.000697443,0.0001968465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001206506,"about_ca_system_score_gemma":0.0001908982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000556507,"about_ca_topic_score_gemma":0.0009759914,"domain_scores_codex":[0.9999388,0.00001280655,0.000007324968,0.00001026563,0.00001420323,0.00001659256],"domain_scores_gemma":[0.9999576,0.000007144195,0.00001288176,0.000006188278,0.000006240264,0.00001008746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003390787,0.0001177624,0.0001959029,0.0001037454,0.00001889883,0.00004808157,0.00001804091,0.00004835707,0.9962422,0.00002846208,0.00009378698,0.002745822],"study_design_scores_gemma":[0.0002015282,0.003027779,0.01686594,0.00002914216,0.0001289836,0.0005228207,0.00008603565,0.001001569,0.9699384,0.00009276449,0.008093162,0.00001187205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990729,0.005446715,0.001614662,0.0001960336,0.00007645689,0.00005477119,0.0007133536,0.0001284153,0.001040615],"genre_scores_gemma":[0.9912549,0.002890743,0.002240297,0.0001640785,0.00004016383,0.00006325459,0.001534859,0.00002285391,0.001788773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157371,"threshold_uncertainty_score":0.003871799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00617794131480865,"score_gpt":0.2862036355658064,"score_spread":0.2800256942509977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}