{"id":"W2050728259","doi":"10.4161/cc.10.13.16248","title":"MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression","year":2011,"lang":"en","type":"article","venue":"Cell Cycle","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancerföreningen i Stockholm; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Research Society; Johns Hopkins University; Howard Hughes Medical Institute","keywords":"Biology; Cell division control protein 4; Ubiquitin ligase; Cyclin A; F-box protein; Cell biology; Cyclin E; microRNA; Cyclin D; Ubiquitin; Cell cycle; Cyclin A2; Cyclin B; Cell cycle checkpoint; Mdm2; Carcinogenesis; Cancer research; Cyclin; Genetics; Cell; Cell culture; Cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323632,0.0001830699,0.0002334947,0.0002251532,0.000189893,0.000343435,0.0001922561,0.0001603332,0.0009377201],"category_scores_gemma":[0.0002324735,0.0001545693,0.0001843566,0.00008421564,0.0002725337,0.0001281559,0.0002167576,0.0003047182,0.0005292413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000388233,"about_ca_system_score_gemma":0.0003547785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006724557,"about_ca_topic_score_gemma":0.0008657294,"domain_scores_codex":[0.9998569,0.00002523274,0.00001160626,0.00004161454,0.00002905063,0.0000355096],"domain_scores_gemma":[0.9998597,0.00002391069,0.00003777562,0.00001606645,0.00002150523,0.00004104229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002267393,0.00002167629,0.0003821282,0.00001200377,0.000003668273,0.00005139506,0.00001279731,0.00005649695,0.9975431,0.0001750267,0.00005272959,0.00146223],"study_design_scores_gemma":[0.00001728768,0.0001207331,0.004298188,0.000002049704,0.000008439174,0.0001558187,0.00002239689,0.002055043,0.990889,0.00008492447,0.002342363,0.000003889741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926865,0.001433719,0.003321455,0.00009607692,0.00004493605,0.00002080964,0.0002352703,0.0001377465,0.002023448],"genre_scores_gemma":[0.9952553,0.0004039672,0.001717943,0.000026991,0.000007193498,0.00002511551,0.0001979403,0.00003698497,0.002328539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009377201,"threshold_uncertainty_score":0.003136992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00969768260009326,"score_gpt":0.2331003973293379,"score_spread":0.2234027147292446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}