{"id":"W2050728259","doi":"10.4161/cc.10.13.16248","title":"MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression","year":2011,"lang":"en","type":"article","venue":"Cell Cycle","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancerföreningen i Stockholm; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Research Society; Johns Hopkins University; Howard Hughes Medical Institute","keywords":"Biology; Cell division control protein 4; Ubiquitin ligase; Cyclin A; F-box protein; Cell biology; Cyclin E; microRNA; Cyclin D; Ubiquitin; Cell cycle; Cyclin A2; Cyclin B; Cell cycle checkpoint; Mdm2; Carcinogenesis; Cancer research; Cyclin; Genetics; Cell; Cell culture; Cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001611815,0.0001807621,0.0001378238,0.00004116447,0.000105426,0.00003252113,0.0001456464,0.0001866982,0.00009503815],"category_scores_gemma":[0.00002090445,0.0001736657,0.00006963747,0.00004881241,0.00007101714,0.000012419,0.0001110772,0.00007995546,0.00004962067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001928667,"about_ca_system_score_gemma":0.00004040162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000371135,"about_ca_topic_score_gemma":0.00001660377,"domain_scores_codex":[0.9988543,0.00007830166,0.0002393811,0.0004214779,0.0001502912,0.0002562673],"domain_scores_gemma":[0.9992558,0.000009580745,0.000155499,0.0003645353,0.00006497313,0.0001495715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000130699,0.000222185,0.003790566,0.00004614139,0.0000134882,0.000004896048,0.00008623566,0.00001866925,0.9923544,0.00002134188,0.0004396445,0.002871749],"study_design_scores_gemma":[0.001302032,0.0001597825,0.01782702,0.00001867064,0.00004248767,0.000006550399,0.00005077515,0.0004084587,0.9772645,0.000359378,0.002312757,0.0002475453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991694,0.001759026,0.001040581,0.00003082416,0.0001241331,0.0004009785,0.00001787608,0.00003025518,0.004902322],"genre_scores_gemma":[0.9971424,0.0001201948,0.00159658,0.00007838488,0.0001218781,0.00003823312,0.0001592745,0.00003400094,0.0007090871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01508984,"threshold_uncertainty_score":0.7081884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00969768260009326,"score_gpt":0.2331003973293379,"score_spread":0.2234027147292446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}