{"id":"W2050728617","doi":"10.1002/pbc.22484","title":"Imatinib mesylate in children and adolescents with cancer","year":2010,"lang":"en","type":"review","venue":"Pediatric Blood & Cancer","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Memorial Sloan-Kettering Cancer Center","keywords":"Medicine; Imatinib; Imatinib mesylate; Myeloid leukemia; Tyrosine-kinase inhibitor; Oncology; Philadelphia chromosome; Tyrosine kinase; Leukemia; Cancer; Platelet-derived growth factor receptor; Internal medicine; Cancer research; Receptor; Chromosomal translocation; Growth factor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001316863,0.0007592038,0.002204858,0.0004001649,0.00005432691,0.00003032272,0.0002048972,0.0005394047,0.0002807113],"category_scores_gemma":[0.00002667412,0.0005289439,0.0002063301,0.0007272462,0.00007688925,0.00007592948,0.0001121961,0.001406401,0.00003256467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005713425,"about_ca_system_score_gemma":0.003036845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002840508,"about_ca_topic_score_gemma":0.0007789021,"domain_scores_codex":[0.9972589,0.00006166607,0.0006692939,0.0009109285,0.0004560041,0.0006432064],"domain_scores_gemma":[0.9984894,0.00003800263,0.000510011,0.0005789588,0.0000683278,0.0003152942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004268368,0.0002710042,0.3338044,0.01943905,0.0005012233,0.00008856049,0.00005106967,4.495608e-7,1.506436e-7,0.000001067738,0.0002922642,0.6455081],"study_design_scores_gemma":[0.0343289,0.0006402404,0.2291004,0.0947096,0.08428056,0.001969049,0.000006432722,0.000007834362,0.000005996415,0.000008644734,0.5520058,0.00293655],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0361582,0.9607747,2.461811e-7,0.00003440049,0.0002548491,0.002317282,0.0002772986,0.00006443441,0.0001186119],"genre_scores_gemma":[0.001258214,0.9948289,0.0001423661,0.00008417734,0.001983791,0.001035239,0.0001231739,0.0001683396,0.0003757479],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6425715,"threshold_uncertainty_score":0.9997162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315714555472998,"score_gpt":0.3058714021613215,"score_spread":0.2927142566065915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}