{"id":"W2050729751","doi":"10.1002/humu.10068","title":"Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred","year":2002,"lang":"en","type":"article","venue":"Human Mutation","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"CDH1; Germline mutation; Germline; Cancer; Genetics; Biology; Mutation; Cancer research; Gene; Cadherin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003637,0.0003249791,0.0002287735,0.0009476529,0.0004351666,0.0002131943,0.00009776406,0.0002191376,0.000817971],"category_scores_gemma":[0.001069511,0.0001729196,0.0001284777,0.0004443571,0.000537931,0.0001137244,0.0003207707,0.0001271504,0.00009426735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001926021,"about_ca_system_score_gemma":0.000129175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001974651,"about_ca_topic_score_gemma":0.003380943,"domain_scores_codex":[0.9998331,0.00002949916,0.00001749252,0.00004619542,0.00003847097,0.0000351261],"domain_scores_gemma":[0.9997595,0.00008790158,0.00005193781,0.00002641107,0.00002285557,0.00005130482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004437576,0.00004857633,0.9108951,0.00006662744,0.00008095334,0.01932137,0.001039335,0.0002794282,0.0537421,0.0001852263,0.0003099756,0.01358762],"study_design_scores_gemma":[0.00002949379,0.0002564417,0.9308624,0.00001637966,0.0001113684,0.05883409,0.0004705871,0.0004579606,0.007972652,0.0001467742,0.0008301544,0.00001167482],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996673,0.00009066354,0.00005786661,0.000008961312,7.583678e-7,0.000001081612,0.00001862033,0.000003571032,0.0001511747],"genre_scores_gemma":[0.9997156,0.00009085618,0.00008419074,0.000007535895,0.000001791934,0.000001133191,0.00003636946,0.000001265255,0.00006118731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001974651,"threshold_uncertainty_score":0.003926277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02340192917973442,"score_gpt":0.2821609634007269,"score_spread":0.2587590342209925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}