{"id":"W2050742356","doi":"10.1371/journal.pone.0082363","title":"Resistance to Bleomycin in Cancer Cell Lines Is Characterized by Prolonged Doubling Time, Reduced DNA Damage and Evasion of G2/M Arrest and Apoptosis","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Waterloo; University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"Princess Margaret Hospital Foundation","keywords":"Comet assay; Apoptosis; DNA damage; Cytotoxicity; Bleomycin; Cell culture; Doubling time; Molecular biology; Cell cycle checkpoint; Cell cycle; Biology; Programmed cell death; DNA repair; Andrology; DNA; Medicine; In vitro; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238154,0.0003835149,0.0005202311,0.0006036668,0.0002101228,0.0005043773,0.0002293634,0.0005175363,0.00203407],"category_scores_gemma":[0.0003755836,0.0001438961,0.0003528198,0.0004562391,0.0002373371,0.0002654167,0.0002119811,0.000650588,0.0007666291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117176,"about_ca_system_score_gemma":0.0001687807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005161156,"about_ca_topic_score_gemma":0.0007713822,"domain_scores_codex":[0.9996396,0.00004923216,0.00005918743,0.00007676864,0.000133899,0.00004114933],"domain_scores_gemma":[0.9993646,0.0001148315,0.000250737,0.0001003925,0.0001122748,0.00005727046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008362898,0.00003408985,0.002460283,0.00006725951,0.00001264274,0.00008843533,0.0000205101,0.00005399251,0.9949152,0.00002657283,0.00005556936,0.002181748],"study_design_scores_gemma":[0.000009963484,0.001008912,0.04170371,0.00001476124,0.00003042294,0.001667447,0.00005538889,0.0003351821,0.9521584,0.00004501693,0.002961831,0.000008884977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837878,0.007454443,0.005103955,0.0001931519,0.00003176491,0.00008225734,0.001353921,0.0002111497,0.001781605],"genre_scores_gemma":[0.9921951,0.002182956,0.002136298,0.00007408072,0.00001479104,0.00008988594,0.001556738,0.00002580399,0.001724433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203407,"threshold_uncertainty_score":0.006804645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059845395302509,"score_gpt":0.2335870660210333,"score_spread":0.2129886120680082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}