{"id":"W2050742356","doi":"10.1371/journal.pone.0082363","title":"Resistance to Bleomycin in Cancer Cell Lines Is Characterized by Prolonged Doubling Time, Reduced DNA Damage and Evasion of G2/M Arrest and Apoptosis","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Waterloo; University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"Princess Margaret Hospital Foundation","keywords":"Comet assay; Apoptosis; DNA damage; Cytotoxicity; Bleomycin; Cell culture; Doubling time; Molecular biology; Cell cycle checkpoint; Cell cycle; Biology; Programmed cell death; DNA repair; Andrology; DNA; Medicine; In vitro; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008409515,0.00011608,0.0001980553,0.00003060831,0.00002871251,0.0000225698,0.00007461184,0.00009194676,0.00004471426],"category_scores_gemma":[0.000008803135,0.0001137481,0.00001709983,0.00006686588,0.00002395671,0.000007791767,0.00006460547,0.00004916007,0.000001963957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000123454,"about_ca_system_score_gemma":0.00002574623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001313,"about_ca_topic_score_gemma":0.0000772975,"domain_scores_codex":[0.9992644,0.00002260369,0.0001728927,0.0002848237,0.00009625397,0.0001590443],"domain_scores_gemma":[0.9995643,0.000006721873,0.00007806472,0.0001784502,0.00009809621,0.00007435494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002009495,0.0001760358,0.0001486811,0.0001254802,0.0000377568,9.879633e-8,0.0001095667,1.521553e-7,0.9984462,0.000001100657,0.0002352805,0.000518709],"study_design_scores_gemma":[0.0007991728,0.0001493453,0.0004621625,0.0001331224,0.00003183716,7.008826e-8,0.00002482158,0.00003932847,0.9970347,0.00001487858,0.001175157,0.000135434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996526,0.001944487,0.00001209324,0.0008023108,0.0000203989,0.0005529898,0.00005491381,0.00000497392,0.00008184763],"genre_scores_gemma":[0.9942703,0.002649085,0.0009480435,0.0005340083,0.0000740613,0.0002090846,0.0000355907,0.00002095059,0.001258892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002255701,"threshold_uncertainty_score":0.4638513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059845395302509,"score_gpt":0.2335870660210333,"score_spread":0.2129886120680082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}