{"id":"W2050746528","doi":"10.1002/cncr.25349","title":"Phase 2 trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by surgery for esophageal cancer","year":2010,"lang":"en","type":"article","venue":"Cancer","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"Medicine; Irinotecan; Esophageal cancer; Esophagectomy; Clinical endpoint; Neutropenia; Chemoradiotherapy; Surgery; Esophagitis; Internal medicine; Phases of clinical research; Gastroenterology; Radiation therapy; Cancer; Chemotherapy; Clinical trial; Colorectal cancer; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002165674,0.000192096,0.0005529543,0.00008175154,0.00008529016,0.00002066702,0.0000617773,0.0001084636,0.0007256174],"category_scores_gemma":[0.00006952947,0.0001485913,0.0001441218,0.0001095208,0.0001926124,0.0001117431,0.00001693625,0.0002192902,7.435641e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001783547,"about_ca_system_score_gemma":0.001071936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007954774,"about_ca_topic_score_gemma":0.0003277468,"domain_scores_codex":[0.9987576,0.00002541918,0.0003103745,0.0002790785,0.0002694267,0.000358098],"domain_scores_gemma":[0.9990337,0.0002091959,0.0001219194,0.0001999337,0.0001589822,0.0002761905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4612455,0.003220657,0.03526968,0.001325776,0.002512005,0.0001478591,0.003169226,0.00002511252,0.06785876,0.0005363653,0.09288155,0.3318075],"study_design_scores_gemma":[0.6360837,0.01491031,0.004850837,0.0002838831,0.0005940376,0.0000304055,0.0001238783,0.002888291,0.3133748,0.00004554515,0.02619595,0.0006183698],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821153,0.01324739,0.000161089,0.00081118,0.0005627731,0.002178893,0.0007486169,0.00002430828,0.0001504895],"genre_scores_gemma":[0.9944004,0.001217274,0.0002369156,0.0002548491,0.0005810712,0.001487803,0.00007682261,0.00003234364,0.001712458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3311891,"threshold_uncertainty_score":0.7945002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03037464255402478,"score_gpt":0.3816758591871016,"score_spread":0.3513012166330768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}