{"id":"W2050746528","doi":"10.1002/cncr.25349","title":"Phase 2 trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by surgery for esophageal cancer","year":2010,"lang":"en","type":"article","venue":"Cancer","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"Medicine; Irinotecan; Esophageal cancer; Esophagectomy; Clinical endpoint; Neutropenia; Chemoradiotherapy; Surgery; Esophagitis; Internal medicine; Phases of clinical research; Gastroenterology; Radiation therapy; Cancer; Chemotherapy; Clinical trial; Colorectal cancer; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00167528,0.00165011,0.001619383,0.0003550182,0.0003865843,0.000743677,0.0009813495,0.001370638,0.004737936],"category_scores_gemma":[0.001254064,0.0006007451,0.0009446066,0.0003634606,0.0008657166,0.0006562193,0.0004378519,0.00349096,0.0008466411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009393405,"about_ca_system_score_gemma":0.002022492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008553483,"about_ca_topic_score_gemma":0.001589354,"domain_scores_codex":[0.9995585,0.0002421176,0.00001840665,0.00007766444,0.00003577042,0.00006758526],"domain_scores_gemma":[0.9993033,0.0001336767,0.0001649056,0.00008255742,0.00004017668,0.0002753707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8718486,0.06505261,0.003882426,0.000485457,0.0006404073,0.0001461888,0.0001570546,0.001722911,0.0106896,0.0001872181,0.003145108,0.04204254],"study_design_scores_gemma":[0.7667701,0.2262811,0.003482918,0.00002050792,0.0001803673,0.0001081641,0.00001842759,0.0007282137,0.001243422,0.00008820125,0.001067707,0.00001092042],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907721,0.001115248,0.000550887,0.0005593107,0.00020152,0.004388795,0.0006858081,0.0001242307,0.001601995],"genre_scores_gemma":[0.9758602,0.001616369,0.003087185,0.001642459,0.0003234516,0.01095393,0.002963785,0.00003726559,0.003515316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004737936,"threshold_uncertainty_score":0.01585001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03037464255402478,"score_gpt":0.3816758591871016,"score_spread":0.3513012166330768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}