{"id":"W2050750468","doi":"10.1074/jbc.m210962200","title":"Localization of the 12.6-kDa FK506-binding Protein (FKBP12.6) Binding Site to the NH2-terminal Domain of the Cardiac Ca2+ Release Channel (Ryanodine Receptor)","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Canadian Institutes of Health Research; Uehara Memorial Foundation; New York State Department of Health; Heart and Stroke Foundation of Canada","keywords":"FKBP; Ryanodine receptor; Terminal (telecommunication); Amino terminal; Binding site; Chemistry; Cell biology; Biophysics; Binding domain; Receptor; Biochemistry; Biology; Peptide sequence; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254948,0.0002903759,0.0003013725,0.0001360836,0.0002032453,0.0003200751,0.0002840304,0.0004108045,0.001162656],"category_scores_gemma":[0.000140844,0.0001898816,0.0004234811,0.0001315659,0.0003001936,0.0002190837,0.0002558056,0.0006050207,0.001100841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003908443,"about_ca_system_score_gemma":0.0002161521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001599777,"about_ca_topic_score_gemma":0.001182626,"domain_scores_codex":[0.9998424,0.0000227889,0.00001260817,0.00004771543,0.00003615639,0.00003835981],"domain_scores_gemma":[0.9998463,0.00002965399,0.00005267613,0.00001462205,0.00001399352,0.00004268162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006664977,0.00001618646,0.000186386,0.00001712096,0.000003013631,0.00006571654,0.00001276425,0.00004194806,0.9992921,0.00004957234,0.00001409799,0.0002344535],"study_design_scores_gemma":[0.00002622724,0.00016061,0.02195931,0.00001271728,0.00002884298,0.0008345759,0.00008987067,0.002259425,0.9720101,0.0000699051,0.002534607,0.00001377775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965832,0.0006365461,0.002071702,0.00008558828,0.00001388336,0.000008070463,0.0002339074,0.00001624052,0.0003508939],"genre_scores_gemma":[0.9945121,0.0004232199,0.002555534,0.00005129801,0.000008709054,0.00001292235,0.0008055012,0.000015691,0.001615068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001599777,"threshold_uncertainty_score":0.003889441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124327213373077,"score_gpt":0.234436072009879,"score_spread":0.2220033506725713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}