{"id":"W2050754241","doi":"10.1074/jbc.c600200200","title":"Suppressing Wnt Signaling by the Hedgehog Pathway through sFRP-1","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"GLI1; Wnt signaling pathway; Smoothened; Cyclopamine; Hedgehog; Hedgehog signaling pathway; Signal transduction; Biology; Cell biology; Cancer research; DKK1; Ectopic expression; Cell culture; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175491,0.0004503982,0.0002439875,0.0002185809,0.000101573,0.0003416722,0.0001656506,0.0001761706,0.001033936],"category_scores_gemma":[0.0000958234,0.000163566,0.0003006401,0.0001385751,0.0002275548,0.0001557912,0.000150654,0.0004430696,0.0004556563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002720978,"about_ca_system_score_gemma":0.0001886665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004823108,"about_ca_topic_score_gemma":0.0006615644,"domain_scores_codex":[0.9998496,0.00002224129,0.00001898746,0.0000333099,0.00003679152,0.00003908296],"domain_scores_gemma":[0.9999295,0.00001062668,0.00002762812,0.00001044964,0.000005942716,0.00001573754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004914014,0.000008961802,0.0001379965,0.00003163641,0.000004864568,0.00004726545,0.000006986671,0.00003731051,0.9982823,0.00008371002,0.00004105687,0.00126875],"study_design_scores_gemma":[0.00001954985,0.0001567981,0.003718035,0.000006196877,0.00001894889,0.0003732415,0.00001367979,0.0009096237,0.9903175,0.00005492452,0.004407597,0.000003838119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843708,0.004833904,0.006685219,0.000228849,0.0000481285,0.00004709644,0.0007252384,0.0003457236,0.002715132],"genre_scores_gemma":[0.9912289,0.001984759,0.003507456,0.0000589698,0.00001814167,0.00003120831,0.0006319701,0.00002449587,0.002514089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033936,"threshold_uncertainty_score":0.003458858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02351523276337418,"score_gpt":0.2530681340324575,"score_spread":0.2295529012690833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}