{"id":"W2050791777","doi":"10.1038/nchembio.1654","title":"Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain","year":2014,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":708,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Wellcome Trust; Howard Hughes Medical Institute","keywords":"RNA; Computational biology; Transcriptome; RNA-binding protein; Identification (biology); Domain (mathematical analysis); Biology; Gene; Chemistry; Cell biology; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005028052113457739,"score_gpt":0.2621896907739011,"score_spread":0.2571616386604434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."},"direct_labels":[],"classifier":{"requested":true,"available":true,"version":"metacan-v1-d91a1de5be90","frame_rows_covered":4299418,"decision_targets":["metaresearch","metaepi_narrow","metaepi_broad","bibliometrics","sts","scholarly_communication","open_science","research_integrity","randomized_trial","nonrandomized_trial","observational","systematic_review","meta_analysis","case_report","qualitative","simulation_or_modeling","bench_or_experimental","theoretical_or_conceptual","not_applicable"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame.","warning":null},"prediction":{"classifier_version":"metacan-v1-d91a1de5be90","candidate_union":["bench_or_experimental","theoretical_or_conceptual","not_applicable"],"consensus_intersection":["bench_or_experimental"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"scores":{"codex":{"metaresearch":0.00024414435034714275,"metaepi_narrow":0.000015259021896696422,"metaepi_broad":0,"bibliometrics":0.0001373311970702678,"sts":0.000030518043793392844,"scholarly_communication":0.0002136263065537499,"open_science":0.001007095445181964,"research_integrity":0.00009155413138017853,"randomized_trial":0.000030518043793392844,"nonrandomized_trial":0,"observational":0.00375371938658732,"systematic_review":0,"meta_analysis":0,"case_report":0.000015259021896696422,"qualitative":0.000015259021896696422,"simulation_or_modeling":0.000045777065690089265,"bench_or_experimental":0.9698329137102312,"theoretical_or_conceptual":0.008926527809567406,"not_applicable":0.002883955138475624,"design_other":0.02754253452353704},"gemma":{"metaresearch":0.0002136263065537499,"metaepi_narrow":0.000015259021896696422,"metaepi_broad":0.000015259021896696422,"bibliometrics":0.00006103608758678569,"sts":0.00007629510948348211,"scholarly_communication":0,"open_science":0.00016784924086366064,"research_integrity":0.0002746623941405356,"randomized_trial":0.000015259021896696422,"nonrandomized_trial":0.00006103608758678569,"observational":0.0008545052262149996,"systematic_review":0,"meta_analysis":0,"case_report":0.000030518043793392844,"qualitative":0.000030518043793392844,"simulation_or_modeling":0.00019836728465705348,"bench_or_experimental":0.9931944762340734,"theoretical_or_conceptual":0.018951705195696954,"not_applicable":0.11541924162661174}},"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame."}}