{"id":"W2050792634","doi":"10.1128/jvi.77.16.8948-8956.2003","title":"Local Delivery of CpG Oligodeoxynucleotides Induces Rapid Changes in the Genital Mucosa and Inhibits Replication, but Not Entry, of Herpes Simplex Virus Type 2","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McMaster University Medical Centre","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"CpG Oligodeoxynucleotide; TLR9; Biology; Innate immune system; Herpes simplex virus; Immunology; Virology; CpG site; Virus; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004626026,0.00009421498,0.0003296144,0.0001895142,0.00003217244,0.000003962256,0.00005980628,0.0001075566,0.00008934433],"category_scores_gemma":[0.0001931101,0.00006136791,0.00005465022,0.0001700973,0.0001832821,0.00005485931,0.00001653967,0.0001579812,0.000002402741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002471234,"about_ca_system_score_gemma":0.00008333279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001337032,"about_ca_topic_score_gemma":0.0001495008,"domain_scores_codex":[0.9990487,0.0001622961,0.0004130309,0.0001097901,0.0001395976,0.0001265841],"domain_scores_gemma":[0.9990984,0.000170868,0.000325035,0.0001801235,0.000176464,0.00004912485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002609759,0.00371579,0.04893971,0.0001839569,0.001168639,0.0003224126,0.003499075,0.0000613691,0.4174669,0.001534061,0.0009435852,0.5195547],"study_design_scores_gemma":[0.003784475,0.00370917,0.1814795,0.0000833759,0.0003400823,0.001826403,0.0009589937,0.0000307568,0.7839224,0.0005129992,0.0232326,0.0001192849],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977835,0.00104671,0.00003505412,0.0005981365,0.0000703462,0.000119473,0.000007639181,0.000002492335,0.0003366934],"genre_scores_gemma":[0.9981574,0.001155903,0.0001696045,0.0004442447,0.00004721659,0.000003407251,0.000001497218,0.000007862616,0.00001280328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5194355,"threshold_uncertainty_score":0.2502511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838595230351357,"score_gpt":0.2888925857268655,"score_spread":0.260506633423352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}