{"id":"W2050792634","doi":"10.1128/jvi.77.16.8948-8956.2003","title":"Local Delivery of CpG Oligodeoxynucleotides Induces Rapid Changes in the Genital Mucosa and Inhibits Replication, but Not Entry, of Herpes Simplex Virus Type 2","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McMaster University Medical Centre","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"CpG Oligodeoxynucleotide; TLR9; Biology; Innate immune system; Herpes simplex virus; Immunology; Virology; CpG site; Virus; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322766,0.0004376883,0.0002817653,0.0001512218,0.0001019768,0.0001899257,0.000155655,0.0002862031,0.001235669],"category_scores_gemma":[0.000142032,0.0001841585,0.0002530449,0.00008557208,0.0002297927,0.0001593018,0.0001694558,0.0005894995,0.000244649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001823703,"about_ca_system_score_gemma":0.0002158148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000476255,"about_ca_topic_score_gemma":0.0007435286,"domain_scores_codex":[0.9998853,0.00001827021,0.000008582575,0.00002929545,0.00001982899,0.00003875776],"domain_scores_gemma":[0.9999081,0.00001655233,0.00002326385,0.0000123212,0.000008131795,0.00003166977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001206113,0.00003902923,0.00004270975,0.00004045703,0.000002480767,0.00002432635,0.00000656384,0.00002959121,0.9987292,0.00001676634,0.00001521825,0.0009330723],"study_design_scores_gemma":[0.00004784912,0.002032207,0.002570977,0.00001226917,0.00001837323,0.0001659713,0.00002504898,0.0004704435,0.9935337,0.00002290003,0.00109624,0.000003915066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947122,0.001930649,0.00164688,0.0000750055,0.00006788485,0.00006905595,0.000139104,0.00009927938,0.001259958],"genre_scores_gemma":[0.9935532,0.001264341,0.002182,0.00009791675,0.00002418311,0.00008733657,0.0002486962,0.00002065168,0.002521792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235669,"threshold_uncertainty_score":0.004133701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838595230351357,"score_gpt":0.2888925857268655,"score_spread":0.260506633423352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}