{"id":"W2050798811","doi":"10.1016/j.jinorgbio.2014.06.009","title":"High metal substitution tolerance of anthrax lethal factor and characterization of its active copper-substituted analogue","year":2014,"lang":"en","type":"article","venue":"Journal of Inorganic Biochemistry","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; Laurentian University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Zinc; Anthrax toxin; Histidine; Peptide; Active site; Metal; Cytotoxicity; Metalloprotein; Biochemistry; Dissociation constant; Enzyme; Stereochemistry; In vitro; Fusion protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000801398,0.0001785079,0.0001383779,0.0001376069,0.0001146587,0.0001764809,0.0003210259,0.0001620707,0.001111464],"category_scores_gemma":[0.0002026064,0.00008518925,0.0001249552,0.0001740134,0.0001714177,0.0001090636,0.00007934146,0.0002413117,0.0001914691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001588062,"about_ca_system_score_gemma":0.000113042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001073049,"about_ca_topic_score_gemma":0.0005164913,"domain_scores_codex":[0.9999375,0.0000103446,0.000006596384,0.0000147005,0.00001552927,0.00001531671],"domain_scores_gemma":[0.9998878,0.00002772209,0.00002380161,0.00001850818,0.0000209665,0.00002111603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001269283,0.00001621393,0.0001087077,0.00001517089,0.000002748879,0.00006777271,0.00001521598,0.00006647613,0.9987954,0.00005619364,0.00001604273,0.0007130947],"study_design_scores_gemma":[0.000009504949,0.0001017397,0.0008960214,0.000001315775,0.000005212869,0.0001415773,0.0000131973,0.0003083035,0.9978375,0.00001700166,0.0006652439,0.000003367341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983453,0.000237179,0.0008066023,0.00002299461,0.000005197602,0.000005250065,0.000101634,0.00001928626,0.0004566772],"genre_scores_gemma":[0.998419,0.00006027467,0.0004578195,0.000005189759,0.000002179485,0.000002441564,0.0002262846,0.000006546464,0.0008201546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111464,"threshold_uncertainty_score":0.003718257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009377882972700934,"score_gpt":0.23602586144184,"score_spread":0.2266479784691391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}