{"id":"W2050801792","doi":"10.1016/j.antiviral.2005.08.004","title":"Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses","year":2005,"lang":"en","type":"article","venue":"Antiviral Research","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health","keywords":"Vero cell; Herpes simplex virus; Dendrimer; Microbicide; HSL and HSV; Chemistry; Cytotoxicity; IC50; Virology; Cytotoxic T cell; In vitro; Virus; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003781874,0.000166959,0.0002738759,0.0003779584,0.0002852171,0.00002973846,0.0003274833,0.0001657252,0.000623884],"category_scores_gemma":[0.0005598774,0.0001360047,0.0001079696,0.0003893951,0.0005972924,0.0001931718,0.0001863636,0.0003752813,0.007262442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036708,"about_ca_system_score_gemma":0.000580708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001474292,"about_ca_topic_score_gemma":0.001887574,"domain_scores_codex":[0.9963307,0.001625536,0.000315835,0.0003799807,0.0004822667,0.0008656605],"domain_scores_gemma":[0.9982718,0.0003415844,0.0000646378,0.0004124097,0.0008775373,0.00003208959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001662286,0.0003265477,0.001481611,0.00001032622,0.0002521883,0.000007578892,0.0002129407,0.000003487703,0.6338268,0.00007330651,0.01157416,0.3520648],"study_design_scores_gemma":[0.002304684,0.0002588707,0.005177914,0.00004358837,0.00004732146,0.000005417984,0.0001928638,0.00005170993,0.8845749,0.00009142241,0.107121,0.0001303267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819099,0.005477924,0.000009090943,0.0004054046,0.000060365,0.0005878067,0.0001372928,0.00002750833,0.01138473],"genre_scores_gemma":[0.9963086,0.0004043536,0.00008124096,0.00005983648,0.0000512594,0.00006721464,0.0001917258,0.00002122907,0.002814532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3519345,"threshold_uncertainty_score":0.9935105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1340076992343101,"score_gpt":0.4291419716975172,"score_spread":0.2951342724632071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}