{"id":"W2050829041","doi":"10.1016/j.bmc.2010.10.054","title":"Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Cytotoxicity; Topoisomerase; Chemistry; Doxorubicin; Anthracycline; Stereochemistry; Enzyme; Cell culture; DNA; Mechanism of action; Biochemistry; Non-competitive inhibition; In vitro; Cancer; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003242364,0.0004337672,0.0004525944,0.00004967808,0.0002222203,0.00003182459,0.0002221918,0.0005513262,0.0002351713],"category_scores_gemma":[0.0001084783,0.0004141706,0.0001032908,0.0001833597,0.0004163318,0.00001451227,0.0002504679,0.0004306092,0.000001873286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002800169,"about_ca_system_score_gemma":0.0002033062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001211069,"about_ca_topic_score_gemma":0.0001113178,"domain_scores_codex":[0.9979244,0.00003416809,0.0005166049,0.0007268906,0.000345387,0.0004525581],"domain_scores_gemma":[0.9986079,0.00002786646,0.0002611394,0.0005582818,0.0001901483,0.0003546627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002334632,0.0001340787,0.0003976125,0.0002233469,0.00009444595,0.00001186806,0.0002038253,2.962759e-7,0.9963983,0.0001275859,0.0001549078,0.002020312],"study_design_scores_gemma":[0.002066434,0.0003691578,0.001020946,0.00009725956,0.0001286781,0.0002092125,0.0003632839,0.00002960549,0.9902375,0.0004186291,0.004616254,0.000443029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955657,0.00256561,0.0003103501,0.0004693854,0.0002536723,0.0002700915,0.0001066187,0.00004052966,0.0004180653],"genre_scores_gemma":[0.9969853,0.0009895823,0.0003463569,0.0004231588,0.0006684044,0.00002058106,0.0001778524,0.00006084563,0.0003279046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006160748,"threshold_uncertainty_score":0.999831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005141643544277273,"score_gpt":0.2176223401520811,"score_spread":0.2124806966078038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}