{"id":"W2050829041","doi":"10.1016/j.bmc.2010.10.054","title":"Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Cytotoxicity; Topoisomerase; Chemistry; Doxorubicin; Anthracycline; Stereochemistry; Enzyme; Cell culture; DNA; Mechanism of action; Biochemistry; Non-competitive inhibition; In vitro; Cancer; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002855656,0.0005003013,0.0003788406,0.000365514,0.0002308703,0.0001993368,0.000293972,0.0002680112,0.001582591],"category_scores_gemma":[0.0002482429,0.000255431,0.000334998,0.0004196473,0.0002343006,0.0002367059,0.0001355625,0.0005854925,0.0003015369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805751,"about_ca_system_score_gemma":0.0003563418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002359502,"about_ca_topic_score_gemma":0.002945178,"domain_scores_codex":[0.9997382,0.00007469896,0.0000278265,0.00002799312,0.00005785769,0.00007357467],"domain_scores_gemma":[0.9997786,0.00005651049,0.00004454473,0.00003740373,0.00003923778,0.00004373198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006881884,0.0001032612,0.0001884505,0.00006104622,0.00001964188,0.00004502699,0.00004576098,0.0003695438,0.996663,0.0001372485,0.00009788632,0.001581017],"study_design_scores_gemma":[0.00004353862,0.001522018,0.002381449,0.000006188148,0.00002255116,0.00006521788,0.00002248016,0.0007017295,0.9945821,0.0000215678,0.0006261349,0.000005122416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943535,0.002239071,0.001029645,0.00008178313,0.00007046422,0.00002816351,0.0004728807,0.00004594518,0.001678547],"genre_scores_gemma":[0.9932955,0.002001807,0.0009369137,0.00002774348,0.00003384907,0.00003942444,0.0009298539,0.00001288605,0.002721966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002359502,"threshold_uncertainty_score":0.005294323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005141643544277273,"score_gpt":0.2176223401520811,"score_spread":0.2124806966078038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}